The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.  298:101531-101531. 2022

The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation..  294:19486-19497. 2019

The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation..  294:8351-8360. 2019

The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner..  289:15495-15506. 2014

Matrilin-1 is an inhibitor of neovascularization..  289:14301-14309. 2014

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration..  288:21389-21398. 2013

Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6..  287:41406-41416. 2012

Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1)..  287:26312-26320. 2012

Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells..  287:25325-25334. 2012

Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6)..  287:20111-20121. 2012

GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment..  286:21524-21534. 2011

Attractant binding induces distinct structural changes to the polar and lateral signaling clusters in Bacillus subtilis chemotaxis..  286:2587-2595. 2011

Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin..  285:4455-4463. 2010

Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors..  284:31541-31547. 2009

Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons..  284:8054-8063. 2009

DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia..  283:36665-36675. 2008

Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6..  283:29699-29705. 2008

Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase..  283:2108-2119. 2008

Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a..  283:572-581. 2008

Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+..  282:30406-30413. 2007

Hip is a pro-survival substrate of granzyme B..  282:27865-27874. 2007

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology..  281:26216-26224. 2006

The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties..  281:5500-5505. 2006

Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors..  280:1248-1256. 2005

Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification..  279:54724-54730. 2004

Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase..  279:27059-27068. 2004

IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein..  279:4686-4695. 2004

Roles for an EPO receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.  278:40702-40709. 2003

DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival..  277:47052-47060. 2002

Activation of caspase pathways during iron chelator-mediated apoptosis..  277:25568-25575. 2002

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization..  277:10394-10399. 2002

Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated..  277:5017-5023. 2002

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit..  276:27527-27534. 2001

Integrative signaling by minimal erythropoietin receptor forms and c-Kit..  276:8995-9002. 2001

Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase. Allosteric interactiona between the inhibitory gamma subunit and the noncatalytic cGMP-binding sites..  275:38611-38619. 2000

GATA-1- and FOG-dependent activation of megakaryocytic alpha IIB gene expression..  275:34114-34121. 2000

Intron 1 elements promote erythroid-specific GATA-1 gene expression..  275:22969-22977. 2000

cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits..  274:18813-18820. 1999

Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in Madin-Darby canine kidney cells. (vol 273, pg 21759, 1998).  273:26256-26256. 1998

Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells..  273:21759-21768. 1998

Structural features of the noncatalytic cGMP binding sites of frog photoreceptor phosphodiesterase using cGMP analogs..  273:5557-5565. 1998

Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain..  272:11176-11184. 1997

The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera..  271:16472-16476. 1996

Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2..  270:14500-14504. 1995

Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway..  270:11055-11061. 1995

Erythropoietin-induced transcription at the murine beta maj-globin promoter. A central role for GATA-1..  270:6619-6627. 1995

Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2..  269:21411-21414. 1994

The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells..  269:18291-18294. 1994

Intracellular cGMP concentration in rod photoreceptors is regulated by binding to high and moderate affinity cGMP binding sites..  268:17190-17198. 1993

Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites.  268:8046-8052. 1993

Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells..  267:17055-17060. 1992

Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase..  267:12570-12576. 1992

Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells..  266:609-614. 1991

Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein..  265:190-194. 1990

Cyclic GMP levels and membrane current during onset, recovery, and light adaptation of the photoresponse of detached frog photoreceptors..  264:15384-15391. 1989

Erythropoietin rapidly alters phosphorylation of pp43, an erythroid membrane protein..  262:2933-2936. 1987

CHANGES IN CGMP CONCENTRATION CORRELATE WITH SOME, BUT NOT ALL, ASPECTS OF THE LIGHT-REGULATED CONDUCTANCE OF FROG ROD PHOTORECEPTORS.  261:2965-2975. 1986

Changes in cGMP concentration correlate with some, but not all, aspects of the light-regulated conductance of frog rod photoreceptors..  261:12965-12975. 1986

cGMP influences guanine nucleotide binding to frog photoreceptor G-protein..  261:313-318. 1986

Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors..  259:9635-9641. 1984

Biochemistry & Molecular Biology