Journal of Biological Chemistry
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The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase
The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.
The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation.
The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner.
Matrilin-1 is an inhibitor of neovascularization.
Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration.
Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.
Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1).
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6).
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.
Attractant binding induces distinct structural changes to the polar and lateral signaling clusters in Bacillus subtilis chemotaxis.
Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.
Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors.
Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons.
DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.
Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase.
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+.
Hip is a pro-survival substrate of granzyme B.
Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.
The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties.
Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors.
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.
Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase.
IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein.
Roles for an EPO receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit
DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival.
Activation of caspase pathways during iron chelator-mediated apoptosis.
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization.
Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated.
The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit.
Integrative signaling by minimal erythropoietin receptor forms and c-Kit.
Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase. Allosteric interactiona between the inhibitory gamma subunit and the noncatalytic cGMP-binding sites.
GATA-1- and FOG-dependent activation of megakaryocytic alpha IIB gene expression.
Intron 1 elements promote erythroid-specific GATA-1 gene expression.
cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits.
Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in Madin-Darby canine kidney cells. (vol 273, pg 21759, 1998)
Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells.
Structural features of the noncatalytic cGMP binding sites of frog photoreceptor phosphodiesterase using cGMP analogs.
Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain.
The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera.
Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2.
Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway.
Erythropoietin-induced transcription at the murine beta maj-globin promoter. A central role for GATA-1.
Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.
The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells.
Intracellular cGMP concentration in rod photoreceptors is regulated by binding to high and moderate affinity cGMP binding sites.
Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites
Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells.
Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase.
Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells.
Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein.
Cyclic GMP levels and membrane current during onset, recovery, and light adaptation of the photoresponse of detached frog photoreceptors.
Erythropoietin rapidly alters phosphorylation of pp43, an erythroid membrane protein.
CHANGES IN CGMP CONCENTRATION CORRELATE WITH SOME, BUT NOT ALL, ASPECTS OF THE LIGHT-REGULATED CONDUCTANCE OF FROG ROD PHOTORECEPTORS
Changes in cGMP concentration correlate with some, but not all, aspects of the light-regulated conductance of frog rod photoreceptors.
cGMP influences guanine nucleotide binding to frog photoreceptor G-protein.
Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors.
Has Subject Area
Biochemistry & Molecular Biology
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