Roles for an EPO receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit

Academic Article


  • Erythroid progenitor cell expansion depends upon co-signaling by Epo receptor (EpoR) and Kit, but underlying mechanisms are incompletely understood. To quantitatively analyze EpoR contributions to co-signaling, phosphotyrosine (Tyr(P)) mutants were expressed as human epidermal growth factor (hEGF) receptor-mEpoR EE chimeras at matched and physiological levels in FDCW2 hematopoietic progenitor cells and were assayed for proliferative activities in the absence or presence of endogenous Kit stimulation. Two Tyr(P)-null (but Jak2-coupled) EpoR forms each retained
  • Authors

  • Li, K
  • Miller, C
  • Hegde, S
  • Wojchowski, Don
  • Publication Date

  • October 17, 2003
  • Published In

    Start Page

  • 40702
  • End Page

  • 40709
  • Volume

  • 278
  • Issue

  • 42