Positions

Research Areas research areas

Overview

  • My group studies Medicinal and Environmental Inorganic chemistry with a focus on iron, copper and zinc, both in essential and toxic senses of metal coordination and redox chemistry. We design metal ligands with conjugation to biomolecules and fluorophores in order to probe and modulate cellular metal metabolism of healthy and diseased states. Environmental analysis, sensing and nuclear medicine are also of interest. The Planalp group is currently accepting new graduate students.
  • Selected Publications

    Academic Article

    Year Title
    2024 Interactions and Transport of a Bioconjugated Peptide Targeting the Mitomembrane.Bioconjugate Chemistry.  35:371-380. 2024
    2023 A Telechelic Fluorescent Indicator Based on Polymer Conformational Change for Free Copper(II) Ions.Diversity.  23:9476. 2023
    2023 Development of a Ratiometric Fluorescent Cu(II) Indicator Based on Poly(N-isopropylacrylamide) Thermal Phase Transition and an Aminopyridyl Cu(II) Ligand.Molecules.  28:7097. 2023
    2020 Aggregation of poly(N-isopropylacrylamide) homopolymer by Cu2+ and Zn2+: Significance for ratiometric metal ion indicatorsPolyhedron.  191:114797-114797. 2020
    2019 A Cu(II) Indicator Platform Based on Cu(II) Induced Swelling that Changes the Extent of Fluorescein Self-Quenching.Polymers.  11:E1935. 2019
    2018 Dynamic Aggregation of Poly-N-Isopropylacrylamide Characterized Using Second-Order Scattering.Applied Spectroscopy.  72:1341-1348. 2018
    2017 A bifunctional 2,2 ':6 ',2 ''-terpyridine-based ligand for ratiometric Cu(II) sensingJournal of Coordination Chemistry.  70:1123-1136. 2017
    2016 TAMEisoquin, a novel tripodal fluorescent zinc sensor with high Zn(II) affinity and Zn(II)/Cd(II) selective fluorescence response: Synthesis, coordination geometry, spectroscopy, and comparative response to biometal ionsPolyhedron.  109:147-153. 2016
    2015 Efficient synthesis of a new bifunctional Cu(I) chelatorTetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.  56:4434-4437. 2015
    2015 Influence of PNIPAm on log K(f) of a copolymerized 2,2'-bipyridine: revised bifunctional ligand design for ratiometric metal-ion sensing.Dalton Transactions: an international journal of inorganic chemistry.  44:11887-11892. 2015
    2013 Fluorescent ratiometric indicators based on Cu(II)-induced changes in poly(NIPAM) microparticle volume.Diversity.  13:1341-1352. 2013
    2012 Intermolecular approach to metal ion indicators based on polymer phase transitions coupled to fluorescence resonance energy transfer.The Analyst.  137:4734-4741. 2012
    2011 A ratiometric fluorescent metal ion indicator based on dansyl labeled poly(N-isopropylacrylamide) responds to a quenching metal ion.The Analyst.  136:5006-5011. 2011
    2008 Curcumin: from ancient medicine to current clinical trials.Cellular and Molecular Life Sciences.  65:1631-1652. 2008
    2008 Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators.Journal of Inorganic Biochemistry.  102:150-156. 2008
    2007 Ni(II)-mediated synthesis of the novel tripodal aminopyridyl ligand tamepyr: Coordination geometry and rigidity of complexes with the divalent 3d metals Fe-Zn and with In(III)Polyhedron.  26:197-203. 2007
    2006 Iron chelation in the biological activity of curcumin.Free Radical Biology and Medicine.  40:1152-1160. 2006
    2005 N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigation.Journal of Medicinal Chemistry.  48:7993-7999. 2005
    2005 Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents.Bioorganic and Medicinal Chemistry.  13:5961-5967. 2005
    2005 Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.Blood.  106:3191-3199. 2005
    2005 Pyridine-ring alkylation of cytotoxic r-1,c-3,c-5-tris[(2-pyridylmethyl)amino]cyclohexane chelators: Structural and electronic properties of the Mn-II, Fe-II, Ni-II, Cu-II and Zn-II complexesEuropean Journal of Inorganic Chemistry.  2005:3971-3982. 2005
    2004 Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)--analogue chelators.Dalton Transactions: an international journal of inorganic chemistry.  0:1304-1311. 2004
    2004 Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator.Biochemical Pharmacology.  67:1677-1688. 2004
    2003 Steric effects caused by N-alkylation of the tripodal chelator N,N ',N ''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane (tachpyr): structural and electronic properties of the Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexesDalton Transactions: an international journal of inorganic chemistry.  0:318-324. 2003
    2002 Novel cytotoxic chelators that bind iron(II) selectively over zinc(II) under aqueous aerobic conditions.Biochemical Society Transactions.  30:758-762. 2002
    2002 Activation of caspase pathways during iron chelator-mediated apoptosis.Journal of Biological Chemistry.  277:25568-25575. 2002
    2002 Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.BBA: General Subjects.  1571:211-218. 2002
    2001 Synthesis of novel 1,3,5-cis,cis-triaminocyclohexane ligand based Cu(II) complexes as potential radiopharmaceuticals and correlation of structure and serum stabilityPolyhedron.  20:3155-3163. 2001
    2001 p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator.Carcinogenesis.  22:1607-1614. 2001
    2001 Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 1. Preparation and structure.Inorganic Chemistry: including bioinorganic chemistry.  40:4167-4175. 2001
    2001 Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 2. Metal-promoted phosphate diester hydrolysis.Inorganic Chemistry: including bioinorganic chemistry.  40:4176-4182. 2001
    2000 Effect of metal size on coordination geometry of N,N ',N ''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane: synthesis and structure of [(ML)-L-II] (ClO4)(2) (M = Zn, Cd and Hg)Polyhedron.  19:1155-1161. 2000
    1998 Novel iron complexes and chelators based on cis,cis-1,3,5-triaminocyclohexane: iron-mediated ligand oxidation and biochemical propertiesJournal of Biological Inorganic Chemistry.  3:449-457. 1998
    1998 Tumor Cell Cytotoxicity of a Novel Metal ChelatorBlood.  92:1384-1389. 1998
    1998 Tumor cell cytotoxicity of a novel metal chelator.Blood.  92:1384-1389. 1998
    1998 Syntheses, solubilities and oxygen absorption properties of new cobalt(II) Schiff-base complexesPolyhedron.  17:325-330. 1998
    1998 Synthesis and X-ray crystal structure of N,N ',N ''-tris(2-thienylmethyl)-cis-1,3,5-triaminocyclohexane copper(II) dichloridePolyhedron.  17:603-606. 1998
    1997 Tricationic Metal Complexes ([ML][NO(3)](3), M = Ga, In) of N,N',N"-Tris(2-pyridylmethyl)- cis-1,3,5-triaminocyclohexane: Preparation and Structure.Inorganic Chemistry: including bioinorganic chemistry.  36:4600-4603. 1997
    1996 Preparation of the novel chelating agent N-(2-aminoethyl)-trans-1,2-diaminocyclohexane-N,N',N''-pentaacetic acid (H(5)CyDTPA), a preorganized analogue of diethylenetriaminepentaacetic acid (H(5)DTPA), and the structures of Bi-III(CyDTPA)(2-) and Bi-III(H(2)DTPA) complexesInorganic Chemistry: including bioinorganic chemistry.  35:6343-&. 1996
    1996 An improved synthesis of cis,cis-1,3,5-triaminocyclohexane. Synthesis of novel hexadentate ligand derivatives for the preparation of gallium radiopharmaceuticalsBioorganic and Medicinal Chemistry Letters.  6:807-810. 1996
    1995 SYNTHESIS AND REACTIVITY OF CYCLOPENTADIENYLTITANIUM COMPLEXES OF THE POLYDENTATE ALKOXIDE LIGAND CIS-1,3,5-CYCLOHEXANETRIALKOXIDEPolyhedron.  14:2569-2573. 1995
    1993 THERMOLYSIS OF HALOALUMINIUM AND ALKYLALUMINUM SILYLAMIDO COMPLEXES AND THE AL4N4 CUBANE CORE STRUCTURE OF [I-BUALNSIPH3]4Inorganic Chemistry: including bioinorganic chemistry.  32:2600-2603. 1993
    1993 SYNTHESIS AND CHARACTERIZATION OF RUTHENIUM COMPLEXES CONTAINING TRIDENTATE P3O93-, NB2W4O194-, AND CP-ASTERISK-TIW5O183- LIGANDSInorganic Chemistry: including bioinorganic chemistry.  32:1629-1637. 1993
    1993 SYNTHESIS, STRUCTURE, AND ALCOHOLYSIS OF ETA-5-1,3-BIS(TRIMETHYLSILYL)CYCLOPENTADIENYLTITANIUM CIS-1,3,5-CYCLOHEXANETRIALKOXIDE, AN ADAMANTANE-FRAMEWORK COMPLEX OF A POLYDENTATE ALKOXIDE LIGANDInorganic Chemistry: including bioinorganic chemistry.  32:1062-1063. 1993
    1992 STRUCTURE OF A POLYDENTATE ALKOXIDE LIGAND, CIS-TETRAHYDROXYTETRAMETHYLCYCLOBUTANEActa Crystallographica Section C: Crystal Structure Communications.  48:1902-1904. 1992
    1992 SYNTHESES, STRUCTURES, AND ISOMERIZATION PROCESSES OF DIALKYLALUMINUM SILYLAMIDO COMPLEXESOrganometallics.  11:529-534. 1992
    1989 OPENING OF TRINUCLEAR CLUSTERS BY DIPHOSPHINOMETHANE LIGANDSZeitschrift fuer Naturforschung, Section B: A Journal of Chemical Sciences.  44:139-144. 1989
    1989 Öffnung von Dreikernclustern durch Diphosphinomethan-Liganden / Opening of Trinuclear Clusters by Diphosphinomethane LigandsZeitschrift fuer Naturforschung, Section B: A Journal of Chemical Sciences.  44:139-144. 1989
    1987 REVERSIBLE METAL METAL BOND-CLEAVAGE IN FECO2 AND FECOW CLUSTERSOrganometallics.  6:492-499. 1987
    1985 STRUCTURE OF (ETA-CYCLOPENTADIENYL)((3RSTAR,3ARSTAR)-5-5A-9A-9B-ETA-3-METHOXY-5-TRIMETHYLSILYL-2,3,3A,4,6,7,8,9-OCTAHYDRO-1H-BENZ[E]INDENE)COBALT,[CO(C5H5)(C17H28OSI)]Acta Crystallographica Section C: Crystal Structure Communications.  41:833-835. 1985
    1983 CLEAVAGE OF CARBON-MONOXIDE BY MONONUCLEAR ZIRCONIUM DIALKYLS - FORMATION OF A (MU-OXO)DIALKYL AND AN ENOLATEJournal of the American Chemical Society.  105:7774-7775. 1983
    1983 DIALKYL BIS[BIS(TRIMETHYLSILYL)AMIDE] GROUP 4A COMPOUNDS - PHOSPHINE-INDUCED TRANSFORMATION OF A BRIDGING CARBENE INTO A METALLACYCLE - CRYSTAL-STRUCTURE OF ZR[CH2SI(ME)2NSIME3]2(ME2PCH2CH2PME2)Organometallics.  2:1675-1680. 1983
    1983 DIALKYL BIS[BIS(TRIMETHYLSILYL)AMIDO] GROUP-4A METAL-COMPLEXES - PREPARATION OF BRIDGING CARBENE COMPLEXES BY GAMMA-ELIMINATION OF ALKANE - CRYSTAL-STRUCTURE OF [ZRCHSI(ME)2NSIME3[N(SIME3)2])2Organometallics.  2:16-20. 1983
    Bimetallic Fenton-like Catalysts in the Remediation of DyesColorants.  3:1-16.

    Conference Paper

    Year Title
    2014 Characterization of retinal phosphodiesterase: Dependence of activity on zinc and cadmium concentrationACS National Meeting Book of Abstracts. 2014
    2014 Synthesis of ligands and polymers for fluorescent ratiometric sensor of Cu (II)ACS National Meeting Book of Abstracts. 2014
    2014 Synthesis, characterization, and formation constant studies of novel bifunctional ligands for sensing copper, zinc, and ironACS National Meeting Book of Abstracts. 2014
    2013 Influence of ligand structure on Fe(II) spin-state and cytotoxicity of tripodal chelatorsACS National Meeting Book of Abstracts. 150-156. 2013
    2013 Modular approach towards ratiometric sensing of metal ions in the environmentACS National Meeting Book of Abstracts. 2013
    2012 Copolymerizable ligands for ratiometric Cu2+ sensing in a fluorescent polymer indicatorACS National Meeting Book of Abstracts. 2012
    2011 Bifunctional ligands, and their incorporation in a ratiometric indicator for divalent copperACS National Meeting Book of Abstracts. 2011
    2011 Design, synthesis and characterization of novel bifunctional ligands for use in a copper sensorACS National Meeting Book of Abstracts. 2011
    2010 Characterization of stability and protonation constants of novel bifunctional ligands for use in a copper sensorACS National Meeting Book of Abstracts. 2010
    2010 Fluorescent ratiomeric Cu(II) indicator based on poly(N-isopropylacrylamide) labeled with a donor, an acceptor, and a ligandACS National Meeting Book of Abstracts. 2010
    2009 Preparation and binding studies of polymerizable Cu2+ receptors for use in novel sensorsACS National Meeting Book of Abstracts. 2009
    2009 Preparation of novel bifunctional ligands for copper(II)ACS National Meeting Book of Abstracts. 2009
    2008 ANYL 45-Novel preparation of fluorescent poly(N-isopropylacrylamide) polymers and routes to functionalization for metal ion sensing at the PPB levelACS National Meeting Book of Abstracts. 2008
    2008 INOR 20-Iron coordination chemistry of curcumin and metabolitesACS National Meeting Book of Abstracts. 2008
    2008 INOR 186-Iron coordination and redox chemistry of curcuminoidsACS National Meeting Book of Abstracts. 2008
    2007 ANYL 438-Synthesis of weakly-chelating monomers and copolymerization with N-isopropylacrylamide to provide ratiometric metal ion sensing polymersACS National Meeting Book of Abstracts. 2007
    2007 INOR 34-Novel tripodal aminoisoquinolyl-based sensors designed for selective Zn detection and luminescence approaching the visible spectrumACS National Meeting Book of Abstracts. 2007
    2007 INOR 693-Iron coordination chemistry of curcumin and derivativesACS National Meeting Book of Abstracts. 285-285. 2007
    2007 INOR 788-Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelatorsACS National Meeting Book of Abstracts. 314-314. 2007
    2006 INOR 653-Novel fluorescent sensors for Zn(II)ACS National Meeting Book of Abstracts. 2006
    2006 INOR 666-Evaluation of substituent effects in four- and six-coordinate aminopyridyl metal chelatorsACS National Meeting Book of Abstracts. 2006
    2006 MEDI 260-The metal-complexation properties of cytotoxic tripodal hexadentate chelators: Effects of heterocycle donor arms on Fe(II) chelation and fibroblast IC50 valueACS National Meeting Book of Abstracts. 2006
    2005 Polyamino-heterocycle chelating agents with cytotoxic activity in tumor cells: Structure-activity relationship of imidazole, thiazole and pyridyl donor groups.ACS National Meeting Book of Abstracts. U205-U205. 2005
    2005 Polyamino-heterocycle chelating agents with cytotoxic activity in tumor cells: Structure-activity relationship of imidazole, thiazole and pyridyl donor groups.ACS National Meeting Book of Abstracts. U199-U199. 2005
    2005 Synthesis of a novel tripodal ligand based on the tame framework and its coordination chemistry with Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II).ACS National Meeting Book of Abstracts. U1000-U1000. 2005
    2004 N-picolyl derivatives of Kemp's triamine as potential antitumor agents: Preliminary investigations.ACS National Meeting Book of Abstracts. U792-U792. 2004
    2004 Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)analogue chelators.ACS National Meeting Book of Abstracts. U843-U843. 2004
    2004 Synthesis of N,N ',N '' trispyridylmethylene(2-aminoethyl)amine walkylated derivatives as potential anti-tumor agents.ACS National Meeting Book of Abstracts. U846-U846. 2004
    2004 Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)-analogue chelators.ACS National Meeting Book of Abstracts. U1303-U1303. 2004
    2003 Electronic properties and structures of novel Cu(II) complexes of hexadentate aminopyridyl ligands and their alkylated derivatives.ACS National Meeting Book of Abstracts. U748-U748. 2003
    2003 Metal-complexation properties of tripodal hexadentate chelators: Effects of heterocycle donor arms, tripod framework and imine formation on Fe(II) chelation and cytotoxicity.ACS National Meeting Book of Abstracts. U680-U681. 2003
    2000 Pathways of iron chelator actionThe FASEB Journal. A752-A752. 2000
    1999 Evaluation of the biological end cytotoxic properties of CIS,CIS-1,3,5-triaminocyclohexane Cu(II) complexes.ACS National Meeting Book of Abstracts. U834-U835. 1999
    1999 Metal complexation behavior and cytotoxicity of novel hexadentate chelators.ACS National Meeting Book of Abstracts. U991-U991. 1999
    1999 Synthesis and chracterization of dicationic metal complexes of tachpyr and tach-6-Mepyr ligands derived from the cis-1,3,5-triaminocyclohexane framework.ACS National Meeting Book of Abstracts. U868-U868. 1999
    1998 Iron complexes of chelators based on cis,cis-1,3,5-triaminocyclohexane.ACS National Meeting Book of Abstracts. U164-U164. 1998
    1998 Structural and steric effect study of metal complexes of novel hexadentate ligands derived from cis-1, 3, 5-triaminocyclohexane framework.ACS National Meeting Book of Abstracts. U195-U195. 1998
    1996 Facile synthesis of cis,cis-1,3,5-triaminocyclohexane and its use in synthesis of novel hexadentate chelating agents as radiopharmaceuticals.ACS National Meeting Book of Abstracts. 236-ORGN. 1996
    1996 Metal complexes of novel hexadentate ligands based on the cis-1,3,5-triaminocyclohexane framework: Synthesis, structure and stability under biological conditions.ACS National Meeting Book of Abstracts. 559-INOR. 1996
    1996 Titanium and vanadium complexes of the tripropoxideamine derivative ligand, N(Ch(2)C(Ch(3))(2)O-)(3).ACS National Meeting Book of Abstracts. 438-INOR. 1996
    1994 SYNTHESES, SOLUBILITIES AND OXYGEN ABSORPTION PROPERTIES OF NEW COBALT(II) SCHIFF-BASE COMPLEXESACS National Meeting Book of Abstracts. 255-INOR. 1994
    1992 PREPARATION OF METAL POLYALKOXIDE COMPLEXES, CP'TI(O3C6H9)ACS National Meeting Book of Abstracts. 18-INOR. 1992
    1991 A THERMAL SWING ABSORPTION PROCESS FOR PRODUCTION OF OXYGEN-ENRICHED COMBUSTION AIRACS National Meeting Book of Abstracts. 23-IEC. 1991
    1991 DIALKYLALUMINUM MONOSILYLAMIDES - SYNTHESIS, STRUCTURE, ISOMERIZATION, AND THERMAL-DECOMPOSITIONACS National Meeting Book of Abstracts. 247-INOR. 1991
    1989 POLY (ALUMINUM AMIDES) - PREPARATION, RING DYNAMICS, AND CAGE FORMATIONACS National Meeting Book of Abstracts. 377-INOR. 1989
    1988 SYNTHESIS AND LIGAND-EXCHANGE REACTIONS OF ORGANORUTHENIUM POLYPHOSPHATES AND NIOBOTUNGSTATESACS National Meeting Book of Abstracts. 56-INOR. 1988
    1986 METAL-METAL BOND-CLEAVAGE, PHOSPHINE SUBSTITUTION, AND FRAMEWORK RACEMIZATION IN CLUSTERSACS National Meeting Book of Abstracts. 65-INOR. 1986
    1982 SYNTHESIS OF METALLACYCLIC AND BRIDGING-CARBENE DERIVATIVES OF ZIRCONIUM AND HAFNIUMACS National Meeting Book of Abstracts. 212-INOR. 1982

    Teaching Activities

  • Experimental Inorganic Chem Taught course 2023
  • Experimental Inorganic Chem Taught course 2023
  • Adv Inorganic Chemistry I Taught course 2022
  • Student Research Experience Taught course 2022
  • Adv Inorganic Chemistry II Taught course 2022
  • Chem Across Periodic Table Taught course 2022
  • Chem Across Periodic Table Taught course 2022
  • Student Research Experience Taught course 2022
  • Student Research Experience Taught course 2021
  • Chem Across Periodic Table Taught course 2021
  • Chem Across Periodic Table Taught course 2021
  • Adv Inorganic Chemistry I Taught course 2020
  • Adv Inorganic Chemistry I Taught course 2020
  • Inorganic Chemistry Taught course 2020
  • Adv Rsrch Exp/Chemistry Taught course 2020
  • Chem Across Periodic Table Taught course 2020
  • Chem Across Periodic Table Taught course 2020
  • Independent Study Taught course 2020
  • Rsrch Exp/Chemistry Taught course 2020
  • Rsrch Exp/Chemistry Taught course 2019
  • Seminar Taught course 2019
  • Spectroscopic Inv Organc Molec Taught course 2019
  • Adv Inorganic Chemistry II Taught course 2019
  • Inorganic Chemistry Laboratory Taught course 2019
  • Sem/Analytical-Physical Taught course 2018
  • Sem/Organic-Inorganic Taught course 2018
  • Spectroscopic Inv Organc Molec Taught course 2018
  • Inorganic Chemistry Laboratory Taught course 2018
  • Thesis Taught course 2018
  • Spectroscopic Inv Organc Molec Taught course 2017
  • Thesis Taught course 2017
  • Adv Inorganic Chemistry II Taught course 2017
  • Inorganic Chemistry Laboratory Taught course 2017
  • Inorganic Chemistry Taught course 2016
  • Inorganic Biochemistry Taught course 2016
  • Inorganic Chemistry Laboratory Taught course 2016
  • Thesis Taught course 2016
  • Inorganic Chemistry Taught course 2015
  • Thesis Taught course 2015
  • Adv Inorganic Chemistry II Taught course 2015
  • Inorganic Chemistry Laboratory Taught course 2015
  • Adv Inorganic Chemistry I Taught course 2014
  • Sem/Organic-Inorganic Taught course 2014
  • Inorganic Biochemistry Taught course 2014
  • Inorganic Chemistry Laboratory Taught course 2014
  • Thesis Taught course 2014
  • Education And Training

    Full Name

  • Roy Planalp