3D-Printed Self-Assembling Helical Models for Exploring Viral Capsid Structures.

Academic Article

Abstract

  • This work presents a novel application of additive manufacturing in the design of self-assembling helical viral capsids using 3D-printed components. Expanding on prior work with 3D-printed self-assembling spherical capsids, we developed helical models that integrate geometric parameters and magnetic interactions to mimic key features of the assembly process of helical viral capsids. Using dual-helix phyllotactic patterns and simplified electrostatic simulations, these models consistently self-assemble into a cylinder, providing unique insights into the structural organization and stability of helical capsids. This accessible 3D-printed approach demonstrates the potential of additive manufacturing for research in mesoscale self-assembling models and in the education of complex biological assembly processes, promoting hands-on exploration of viral architecture and self-assembly mechanisms.
  • Authors

  • Plante, Donald
  • Unzen, Keegan
  • Jungck, John R
  • Publication Date

  • December 16, 2024
  • Published In

    Keywords

  • 3D-printing
  • 4D-printing
  • TMV
  • capsid
  • capsomere
  • helical
  • helix
  • self-assembly
  • virus
  • Digital Object Identifier (doi)

    Start Page

  • 763
  • Volume

  • 9
  • Issue

  • 12