Experimental sleep fragmentation impairs attentional set-shifting in rats.

Academic Article


  • STUDY OBJECTIVE: To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats. DESIGN: A sleep fragmentation paradigm of intermittent forced locomotion was validated in adult rats by examining electrographic effects. Discrimination task performances were assessed in rats following sleep fragmentation or 2 control conditions. PARTICIPANTS: 41 young adult male Fischer-Norway rats. INTERVENTION: A treadmill was used to produce 30 awakenings/h for the 24-h period prior to testing. Exercise control rats received an equivalent amount of treadmill-induced locomotion that permitted 30-minute pauses to allow consolidated sleep. MEASUREMENT AND RESULTS: SI rats were selectively impaired on the extradimensional-shift phase of the task, taking significantly more trials to achieve criterion performance (15.4 +/- 2.0) than either control group (cage control = 10.4 +/- 0.9; exercise control = 6.3 +/- 0.2). The SI schedule reduced the average duration of nonREM sleep (NREMS) episodes to 56 s (baseline = 182 s), while the exercise control group increased average NREMS episode duration to 223 s. Total (24-h) NREMS time declined from 50% during baseline to 33% during SI, whereas rapid eye movement sleep (REMS) was absent in SI animals (7% during baseline and 0% during SI), and time spent awake increased proportionally (from 43% during baseline to 67% during SI). CONCLUSION: 24-hour SI produced impairment in an attentional set-shifting that is comparable to the executive function and cognitive deficits observed in humans with sleep apnea or after a night of experimental sleep fragmentation.
  • Authors

  • McCoy, John G
  • Tartar, Jaime L
  • Bebis, Alaina C
  • Ward, Christopher P
  • McKenna, James T
  • Baxter, Mark G
  • McGaughy, Jill
  • McCarley, Robert W
  • Strecker, Robert E
  • Status

    Publication Date

  • January 2007
  • Published In

  • Sleep  Journal
  • Keywords

  • Animals
  • Appetitive Behavior
  • Attention
  • Color Perception
  • Discrimination Learning
  • Motivation
  • Psychomotor Performance
  • Rats
  • Rats, Inbred BN
  • Reaction Time
  • Reversal Learning
  • Set, Psychology
  • Sleep Deprivation
  • Sleep Stages
  • Smell
  • Digital Object Identifier (doi)

    Pubmed Id

  • 17310865
  • Start Page

  • 52
  • End Page

  • 60
  • Volume

  • 30
  • Issue

  • 1