Since the early 1990s online education and online learning systems have held the promise of increasing instructional productivity and reducing costs without sacrificing educational quality. There is no evidence to date that such promise has materialized. The impetus of the newest developments with free online courses to hundreds of thousands of students might drastically transform how we teach more and better with less. The innovation that prompted this panel is called Interactive Learning Online (ILO), and has the distinctive feature of highly interactive, machine-guided instruction that can be scaled to accommodate a large number of students who benefit from targeted and personalized learning. The panelists have experimented with online learning in different ways. Their perspectives will address challenges and opportunities with the adoption of ILO systems.