Developing estimates of frequency and intensity of exposure to three types of metalworking fluids in a population-based case-control study of bladder cancer.

Academic Article


  • BACKGROUND: A systematic, transparent, and data-driven approach was developed to estimate frequency and intensity of exposure to straight, soluble, and synthetic/semi-synthetic metalworking fluids (MWFs) within a case-control study of bladder cancer in New England. METHODS: We assessed frequency using individual-level information from job-specific questionnaires wherever possible, then derived and applied job group-level patterns to likely exposed jobs with less information. Intensity estimates were calculated using a statistical model developed from measurements and determinants extracted from the published literature. RESULTS: For jobs with probabilities of exposure≥0.5, median frequencies were 8-10 hr/week, depending on MWF type. Median intensities for these jobs were 2.5, 2.1, and 1.0 mg/m3 for soluble, straight, and synthetic/semi-synthetic MWFs, respectively. CONCLUSIONS: Compared to case-by-case assessment, these data-driven decision rules are transparent and reproducible and may result in less biased estimates. These rules can also aid future exposure assessments of MWFs in population-based studies.
  • Authors

  • Friesen, Melissa C
  • Park, Dong-Uk
  • Colt, Joanne S
  • Baris, Dalsu
  • Schwenn, Molly
  • Karagas, Margaret R
  • Armenti, Karla
  • Johnson, Alison
  • Silverman, Debra T
  • Stewart, Patricia A
  • Status

    Publication Date

  • August 2014
  • Keywords

  • Adult
  • Case-Control Studies
  • Decision Support Techniques
  • Humans
  • Industrial Oils
  • Lubrication
  • Male
  • Metallurgy
  • Middle Aged
  • New England
  • Occupational Exposure
  • Probability
  • Surveys and Questionnaires
  • Urinary Bladder Neoplasms
  • bladder cancer
  • case-control study
  • exposure prediction model
  • metalworking fluids
  • retrospective exposure assessment
  • Digital Object Identifier (doi)

    Start Page

  • 915
  • End Page

  • 927
  • Volume

  • 57
  • Issue

  • 8