Positions

Research Areas research areas

Overview

  • Electrospray is one of the most popular ionization methods for mass spectrometry (ESI-MS). Despite being routinely applied in the analysis of organic and biological molecules, it has many limitations that are usually addressed by additional efforts in sample preparation. We lack a thorough understanding of these limitations.

    The Li+ group has been focused on a few fundamental questions regarding ESI-MS. Where are the limits for the lowest flow rate and ionization current? What is, and how to generate the smallest possible initial charged droplet? What are the characteristics of an "ideal" ESI source and how can we build one? We believe these questions will lead us to expand our knowledge, and eventually to overcome the limitations one by one.

    Our research receives funding from NSF and industry collaborators.

    We are actively recruiting students at all levels.
  • Selected Publications

    Academic Article

    Year Title
    2023 Ultra-low current electrospray ionization of chloroform solution for the analysis of perfluorinated sulfonic acids.Rapid Communications in Mass Spectrometry.  37 Suppl 1:e9501. 2023
    2023 Gigaohm and Teraohm Resistors in Femtoamp and Picoamp Electrospray Ionization.Journal of the American Society for Mass Spectrometry.  34:913-921. 2023
    2022 Conducting and characterizing femto flow electrospray ionization.The Analyst.  147:1071-1075. 2022
    2021 Conducting and Characterizing Femto Flow Electrospray Ionization 2021
    2021 Femtoamp and picoamp modes of electrospray and paper spray ionizationInternational Journal of Mass Spectrometry.  469:116696-116696. 2021
    2021 A paradigm shift fully self-powered long-distance wireless sensing solution enabled by discharge-induced displacement current.Science advances.  7:eabi6751. 2021
    2020 Nested-channel for on-demand alternation between electrospray ionization regimes.Chemical Science.  12:1907-1914. 2020
    2020 Measurement of the Proton Affinities of a Series of Mono- and Biradicals of Pyridine.Journal of the American Chemical Society.  142:8679-8687. 2020
    2019 Compositional characterization of complex protopeptide libraries via triboelectric nanogenerator Orbitrap mass spectrometry.Rapid Communications in Mass Spectrometry.  33:1293-1300. 2019
    2019 Conversion of Ethanol via C-C Splitting on Noble Metal Surfaces in Room-Temperature Liquid-Phase.Journal of the American Chemical Society.  141:9444-9447. 2019
    2018 Triboelectric Nanogenerator (TENG) Mass Spectrometry of Falsified Antimalarials.Rapid Communications in Mass Spectrometry.  32:1585-1590. 2018
    2018 Aerosol Vacuum-Assisted Plasma Ionization (Aero-VaPI) Coupled to Ion Mobility-Mass Spectrometry.Journal of the American Society for Mass Spectrometry.  29:635-639. 2018
    2018 Robotic Surface Analysis Mass Spectrometry (RoSA-MS) of Three-Dimensional Objects.Analytical Chemistry.  90:3981-3986. 2018
    2017 Sizing sub-diffraction limit electrosprayed droplets by structured illumination microscopy.The Analyst.  143:232-240. 2017
    2017 Atmospheric Pressure Drift Tube Ion Mobility-Orbitrap Mass Spectrometry: Initial Performance Characterization.Analytical Chemistry.  89:11301-11309. 2017
    2017 Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry.Nature Nanotechnology.  12:481-487. 2017
    2016 Metallic Nanobrushes Made using Ambient Droplet Sprays.Advanced Materials.  28:2223-2228. 2016
    2015 Hand-held portable desorption atmospheric pressure chemical ionization ion source for in situ analysis of nitroaromatic explosives.Analytical Chemistry.  87:10047-10055. 2015
    2015 On-demand ambient ionization of picoliter samples using charge pulses.Angewandte Chemie International Edition.  54:6893-6895. 2015
    2015 On‐Demand Ambient Ionization of Picoliter Samples Using Charge PulsesAngewandte Chemie International Edition.  127:6997-6999. 2015
    2015 Analysis of polycyclic aromatic hydrocarbons using desorption atmospheric pressure chemical ionization coupled to a portable mass spectrometer.Journal of the American Society for Mass Spectrometry.  26:271-280. 2015
    2014 Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman SpectroscopyAngewandte Chemie International Edition.  126:12736-12739. 2014
    2014 Using ambient ion beams to write nanostructured patterns for surface enhanced Raman spectroscopy.Angewandte Chemie International Edition.  53:12528-12531. 2014
    2014 Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage MetalsAngewandte Chemie International Edition.  126:3211-3214. 2014
    2014 Synthesis and catalytic reactions of nanoparticles formed by electrospray ionization of coinage metals.Angewandte Chemie International Edition.  53:3147-3150. 2014
    2013 Nucleophilic addition of nitrogen to aryl cations: mimicking Titan chemistry.Journal of the American Society for Mass Spectrometry.  24:1745-1754. 2013
    2013 Direct analysis of 4-methylimidazole in foods using paper spray mass spectrometry.The Analyst.  138:4624-4630. 2013
    2013 In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization.The Analyst.  138:3740-3748. 2013
    2013 Hydrocarbon analysis using desorption atmospheric pressure chemical ionizationInternational Journal of Mass Spectrometry.  345:80-88. 2013
    2012 Peptide cross-linking at ambient surfaces by reactions of nanosprayed molecular cations.Angewandte Chemie International Edition.  51:9417-9421. 2012
    2011 Paper spray ionization of polar analytes using non-polar solvents.Chemical Communications.  47:2811-2813. 2011

    Article

    Year Title
    2022 Ultra-low Current Electrospray Ionization of Chloroform Solution for the Analysis of Perfluorinated Sulfonic Acids 2022

    Teaching Activities

  • Advanced Instrumentation Taught course
  • Independent Study Taught course
  • Instrumentation Lab Taught course
  • Instrumentation Lab Taught course
  • Seminar Taught course
  • Student Research Experience Taught course
  • Student Research Experience Taught course
  • Advanced Research Experience Taught course 2024
  • Seminar Taught course 2024
  • Advanced Analytical Chemistry Taught course 2023
  • Instr Method Chem Analysis Lab Taught course 2023
  • Instr Method Chem Analysis Lab Taught course 2023
  • Instrmntl Method Chem Analysis Taught course 2023
  • Student Research Experience Taught course 2023
  • Instr Method Chem Analysis Lab Taught course 2022
  • Instr Method Chem Analysis Lab Taught course 2022
  • Instrmntl Method Chem Analysis Taught course 2022
  • Chemical Equilibria Taught course 2021
  • Student Research Experience Taught course 2021
  • Advanced Analytical Chemistry Taught course 2021
  • Instr Method Chem Analysis Lab Taught course 2021
  • Instr Method Chem Analysis Lab Taught course 2021
  • Instrumental Methd Chem Analy Taught course 2021
  • Quantitative Analysis Lab Taught course 2020
  • Quantitative Analysis Lab Taught course 2020
  • Rsrch Exp/Chemistry Taught course 2020
  • Rsrch Exp/Chemistry Taught course 2020
  • Quantitative Analysis Taught course 2019
  • Quantitative Analysis Lab Taught course 2019
  • Quantitative Analysis Lab Taught course 2019
  • Rsrch Exp/Chemistry Taught course 2019
  • Adv Rsrch Exp/Chemistry Taught course 2019
  • Advanced Analytical Chemistry Taught course 2019
  • Rsrch Exp/Chemistry Taught course 2019
  • Quantitative Analysis Taught course 2018
  • Quantitative Analysis Lab Taught course 2018
  • Quantitative Analysis Lab Taught course 2018
  • Rsrch Exp/Chemistry Taught course 2018
  • Instr Method Chem Analysis Lab Taught course 2018
  • Instr Method Chem Analysis Lab Taught course 2018
  • Rsrch Exp/Chemistry Taught course 2018
  • Quantitative Analysis Taught course 2017
  • Education And Training

    Full Name

  • Anyin Li
  • Mailing Address

  • University of New Hampshire

    Chemistry

    23 Academic Way

    Durham, NH  03824

    United States