Positions

Research Areas research areas

Overview

  • My research focuses on understanding the roles of STATs and related transcription factors in breast and ovarian cancer and we use that knowledge to identify drugs to target the pathways associated with these transcription factors. In my lab, we use a 3D culturing system to mimic advanced stages of cancer. Moreover, we use a combination of wet lab experiments and bioinformatics to identify possible drugs for the treatment of breast and ovarian cancer.
  • Publications

    Academic Article

    Year Title
    2018 IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor MicroenvironmentCancer Research.  78:4957-4970. 2018
    2018 The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer CellsNeoplasia.  20:489-498. 2018
    2016 NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathwaysCell Discovery.  2. 2016
    2016 Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agentBlood.  128:1845-1853. 2016
    2016 Identification of a gain-of-function STAT3 mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndromeBlood.  127:948-951. 2016
    2015 Inhibiting STAT5 by the BET Bromodomain Inhibitor JQ1 Disrupts Human Dendritic Cell MaturationJournal of Immunology.  194:3180-3190. 2015
    2015 The transcriptional modulator BCL6 as a molecular target for breast cancer therapyOncogene.  34:1073-1082. 2015
    2014 Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2Molecular Cancer Therapeutics.  13:1194-1205. 2014
    2014 Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single CellsMolecular Cell.  53:867-879. 2014
    2014 STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF- B to IL-6 Signaling Axis and STAT3-Driven Cancer PhenotypesScience Signaling.  7:ra11-ra11. 2014
    2014 Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancerMolecular and Cellular Endocrinology.  382:616-621. 2014
    2013 STAT5 Outcompetes STAT3 To Regulate the Expression of the Oncogenic Transcriptional Modulator BCL6Molecular and Cellular Biology.  33:2879-2890. 2013
    2013 Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumorsNature Genetics.  45:131-132. 2013
    2012 The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 MutationsGenes and Cancer.  3:503-511. 2012
    2012 Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cellsLeukemia.  26:1407-1410. 2012
    2011 The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumorsJournal of Clinical Investigation.  121:2723-2735. 2011
    2011 The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitorsBlood.  117:3421-3429. 2011
    2010 Microtubule-Targeted Chemotherapeutic Agents Inhibit Signal Transducer and Activator of Transcription 3 (STAT3) SignalingMolecular Pharmacology.  78:903-908. 2010
    2009 Reciprocal Effects of STAT5 and STAT3 in Breast CancerMolecular Cancer Research Cell Growth and Differentiation.  7:966-976. 2009
    2008 Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3Blood.  112:5095-5102. 2008
    2007 STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomasOncogene.  26:224-233. 2007
    2004 Isolation of Unique STAT5 Targets by Chromatin Immunoprecipitation-based Gene IdentificationJournal of Biological Chemistry.  279:54724-54730. 2004
    2004 Electrical wound-healing assay for cells in vitroProceedings of the National Academy of Sciences of the United States of America.  101:1554-1559. 2004
    STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146bCancers.  6:958-968.

    Teaching Activities

  • Tissue Engineering Taught course 2018
  • Tissue Engineering Taught course 2018
  • Education And Training

  • B.S. Bioinformatics and Molecular Biology, Rensselaer Polytechnic Institute
  • B.S. Biology, Rensselaer Polytechnic Institute
  • Ph.D. Cell and Developmental Biology, Harvard University
  • Full Name

  • Sarah Walker
  • Mailing Address

  • University of New Hampshire

    Molecular, Cellular, and Biomedical Sciences

    46 College Rd, Rudman Hall 185

    Durham