Maternal selenium nutrition and neonatal immune system development.

Academic Article

Abstract

  • We evaluated the impact of dietary selenium intake on neonatal immune cell differentiation and function. A low selenium intake during pregnancy and lactation produced reductions in maternal plasma selenium (33%, p = 0.0001), milk selenium (36%, p = 0.001), and corresponding neonatal plasma selenium (47%, p = 0.008). Thymocytes from neonates receiving low-selenium milk showed an impaired activation in vitro (p = 0.001). The percentages of CD8 cytotoxic T cells (p = 0.03), CD2 T cells (p = 0.09), panB cells ( = 0.02), and natural killer cells (p = 0.07) were all decreased in neonates nursed by mothers fed a low-selenium diet. The results indicate that maternal selenium intake impacts neonatal selenium status which in turn influences the neonatal immune system development.
  • Authors

  • Begis, Maggie
  • Mastro, Andrea M
  • Picciano, Mary Francis
  • Status

    Publication Date

  • August 2002
  • Published In

    Keywords

  • Animals
  • Animals, Newborn
  • Anthropometry
  • Cell Differentiation
  • Cell Division
  • Diet
  • Female
  • Immune System
  • Lymphocytes
  • Maternal Nutritional Physiological Phenomena
  • Pregnancy
  • Pregnancy, Animal
  • Rats
  • Rats, Sprague-Dawley
  • Selenium
  • Digital Object Identifier (doi)

    Pubmed Id

  • 12169835
  • Start Page

  • 122
  • End Page

  • 127
  • Volume

  • 82
  • Issue

  • 2