Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity.

Academic Article

Abstract

  • The concentration of the primary brain metabolite of norepinephrine is diminished in the lumbar spinal fluid of patients with Korsakoff's syndrome. The extent of its reduction is significantly correlated with measures of memory impairment for individual patients. These data suggest that the memory disorder of Korsakoff's syndrome may result from damage to ascending noradrenergic pathways by the diencephalic and brainstem lesions associated with this disease.
  • Authors

  • McEntee, WJ
  • Mair, Robert
  • Status

    Publication Date

  • November 24, 1978
  • Published In

    Keywords

  • Alcohol Amnestic Disorder
  • Brain
  • Glycols
  • Homovanillic Acid
  • Humans
  • Hydroxyindoleacetic Acid
  • Memory Disorders
  • Methoxyhydroxyphenylglycol
  • Norepinephrine
  • Vanilmandelic Acid
  • Digital Object Identifier (doi)

    Pubmed Id

  • 715450
  • Start Page

  • 905
  • End Page

  • 907
  • Volume

  • 202
  • Issue

  • 4370