Memory enhancement in Korsakoff's psychosis by clonidine: further evidence for a noradrenergic deficit.

Academic Article


  • Three drugs, d-amphetamine, clonidine, and methysertide, which presumably enhance central noradrenergic activity by different pharmacological mechanisms, were administered to eight patients with the Korsakoff syndrome in a two-week subacute, double-blind, counterbalanced experiment to study the effects of these agents on memory function as measured by a neuropsychological test battery. Of the drugs tested, only clonidine, a putative alpha-noradrenergic agonist, was associated with significant improvement in memory. The data are consistent with the hypothesis that damage to ascending norepinephrine-containing neurons in the brainstem and diencephalon may be the basis for amnesia in Korsakoff's psychosis.
  • Authors

  • McEntee, WJ
  • Mair, Robert
  • Status

    Publication Date

  • May 1980
  • Published In


  • Adult
  • Alcohol Amnestic Disorder
  • Clinical Trials as Topic
  • Clonidine
  • Dextroamphetamine
  • Double-Blind Method
  • Humans
  • Memory
  • Methysergide
  • Middle Aged
  • Neural Pathways
  • Norepinephrine
  • Digital Object Identifier (doi)

    Pubmed Id

  • 6994586
  • Start Page

  • 466
  • End Page

  • 470
  • Volume

  • 7
  • Issue

  • 5