The perimenopausal experience varies among different ethnic and cultural groups. This research examined perimenopausal health self-efficacy of Latinas and non-Hispanic White women and variables that predicted health in 147 women ages 40 to 60 in the Northeast United States. Self-efficacy scores were similar for both groups. Latinas scored lower, however, in the Cognition/Decision Making subscale of the Perimenopausal Health Self-Efficacy Survey (PHS-ES). Perceived health was predicted by control over health and stress for both, and greater self-efficacy was associated with higher perceptions of health. Subtle differences existed between the two groups, which may reflect cultural beliefs and barriers to care during midlife.