Humoral response to an equine encephalitis vaccine in healthy alpacas.

Academic Article

Abstract

  • OBJECTIVE: To determine humoral responses to an equine encephalitis vaccine in healthy alpacas. DESIGN: Clinical trial. ANIMALS: 39 healthy alpacas on 1 farm and 86 healthy alpacas on a second farm. PROCEDURES: All alpacas were given 3 doses IM of a bivalent, killed-virus equine encephalitis vaccine, with 4 weeks between doses. Eastern equine encephalitis (EEE) virus neutralizing antibody responses were determined with a plaque reduction neutralization assay every 14 days in alpacas on the first farm and 70 days after the first dose of vaccine on the second farm. RESULTS: For alpacas on the first farm, geometric mean virus neutralizing antibody titer peaked 2 weeks after the third vaccine dose was given (ie, day 70). At this time, 29 of 38 (76%) animals were seropositive for antibodies against EEE virus, and percentage of animals 6 years old that were seropositive (1/5). For alpacas on the second farm, 76 (88%) were seropositive on day 70, and percentage of animals 6 years old that were seropositive (27/33). For both farms, geometric mean titer on day 70 was significantly higher in animals < 2 years old than in animals > 6 years old. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that inoculation of alpacas with 3 doses of a bivalent, killed-virus equine encephalitis vaccine induced a humoral antibody response against EEE virus.
  • Authors

  • Bedenice, Daniela
  • Bright, Amy
  • Pedersen, Douglas D
  • Dibb, Jack
  • Status

    Publication Date

  • February 15, 2009
  • Keywords

  • Animals
  • Antibodies, Viral
  • Antibody Formation
  • Camelids, New World
  • Dose-Response Relationship, Immunologic
  • Encephalitis Virus, Eastern Equine
  • Encephalomyelitis, Eastern Equine
  • Female
  • Injections, Intramuscular
  • Male
  • Vaccination
  • Vaccines, Inactivated
  • Viral Vaccines
  • Digital Object Identifier (doi)

    Pubmed Id

  • 19222365
  • Start Page

  • 530
  • End Page

  • 534
  • Volume

  • 234
  • Issue

  • 4