The Korsakoff syndrome: a neurochemical perspective.

Academic Article


  • Korsakoff's disease is an amnesic syndrome associated with midline diencephalic and brain stem pathology. A number of neurochemical systems course through or near the loci of brain lesions found postmortem in Korsakoff patients, which has stimulated studies to learn whether these systems are implicated in amnesia. Data suggest that the loss of brain catecholamine function contributes to this amnesic syndrome and may also be a factor in the memory impairments associated with normal aging. At present, data are insufficient to determine whether cholinergic systems are disturbed in Korsakoff's patients; however, it is likely that multiple neurochemical abnormalities underlie this disorder.
  • Authors

  • McEntee, WJ
  • Mair, Robert
  • Status

    Publication Date

  • August 1990
  • Published In


  • Alcohol Amnestic Disorder
  • Humans
  • Nervous System
  • Wernicke Encephalopathy
  • Digital Object Identifier (doi)

    Pubmed Id

  • 1699320
  • Start Page

  • 340
  • End Page

  • 344
  • Volume

  • 13
  • Issue

  • 8