Delayed-nonmatching-to-sample performance is impaired by extensive, but not by limited, lesions of the thalamus in the rat.

Academic Article

Abstract

  • Two experiments were conducted to determine whether lesions affecting limited areas of the thalamus can impair the performance of rats on a spatial delayed-nonmatching-to-sample (DNMTS) task trained before surgery. In Experiment 1, DNMTS was not affected by lesions produced by injecting 5 microliters of 1 mM N-methyl-D-aspartate into either the midline thalamus (n = 16) or bilaterally 1.0 mm from the midline (n = 16). In experiment 2, radio-frequency lesions were made 1.0 mm lateral to the midline at 3 anterior-posterior locations that destroyed the full rostral-caudal extent of the lateral internal medullary lamina (L-IML; n = 8), or at single anterior-posterior locations that destroyed either the anterior (n = 8) or posterior (n = 8) portions of the L-IML site. Although complete L-IML lesions disrupted DNMTS performance to an extent comparable to that of another study (Mair & Lacourse, 1992), lesions that were restricted to either the anterior or posterior portion of the L-IML site had no significant effect on this task.
  • Authors

  • Mair, Robert
  • grosse Beilage, E
  • Robinson, JK
  • Koger, SM
  • Fox, GD
  • Zhang, YP
  • Status

    Publication Date

  • August 1992
  • Published In

    Keywords

  • Animals
  • Appetitive Behavior
  • Brain Mapping
  • Discrimination Learning
  • Glutamates
  • Glutamic Acid
  • Male
  • Mental Recall
  • Neural Pathways
  • Orientation
  • Rats
  • Receptors, N-Methyl-D-Aspartate
  • Retention (Psychology)
  • Thalamus
  • Thiamine
  • Digital Object Identifier (doi)

    Pubmed Id

  • 1354444
  • Start Page

  • 646
  • End Page

  • 656
  • Volume

  • 106
  • Issue

  • 4