Lesions of specific and nonspecific thalamic nuclei affect prefrontal cortex-dependent aspects of spatial working memory.

Academic Article


  • Three studies compared lesions of specific mediodorsal (MD) and nonspecific midline/intralaminar (M/IL) and ventromedial (VM) thalamic nuclei placed to spare the anterior nuclei. Lesions of MD, M/IL, or VM impaired delayed matching trained with retractable levers, a measure of spatial memory affected by prefrontal cortical lesions. The effects of the MD lesion increased at longer retention intervals and thus appeared delay dependent. The effects of M/IL and VM lesions were delay independent. Even when combined, these lesions had no effect on varying choice radial maze delayed nonmatching, a task sensitive to hippocampal or anterior thalamic (but not prefrontal) lesions. These results demonstrate effects of MD, M/IL, and VM lesions distinct from the contributions of hippocampus or anterior thalamus to spatial memory.
  • Authors

  • Bailey, Kathleen R
  • Mair, Robert
  • Status

    Publication Date

  • April 2005
  • Published In


  • Animals
  • Hippocampus
  • Male
  • Memory
  • Prefrontal Cortex
  • Rats
  • Rats, Long-Evans
  • Space Perception
  • Thalamic Nuclei
  • Digital Object Identifier (doi)

    Pubmed Id

  • 15839787
  • Start Page

  • 410
  • End Page

  • 419
  • Volume

  • 119
  • Issue

  • 2