Multimodal sensory discrimination deficits in Korsakoff's psychosis.

Academic Article


  • A consistent impairment in odor identification was observed among a group of 21 amnesic patients, diagnosed as having Korsakoff's psychosis. In a subsequent study of eight Korsakoff and matched alcoholic control subjects, a comparable olfactory deficit was again demonstrated, as well as impairment in color discrimination and auditory perception. No such deficit was observed for a picture identification task designed to control for the non-sensory demands of the olfactory test. Stepwise multiple regression analysis showed a significant correlation between odor identification scores and the concentration of the primary metabolite of norepinephrine in lumbar cerebrospinal fluid. The data demonstrate a consistent coincidence between memory impairment and deficient sensory perception among patients with Korsakoff's psychosis.
  • Authors

  • Mair, Robert
  • Doty, RL
  • Kelly, KM
  • Wilson, CS
  • Langlais, PJ
  • McEntee, WJ
  • Vollmecke, TA
  • Status

    Publication Date

  • 1986
  • Published In

  • Neuropsychologia  Journal
  • Keywords

  • Adult
  • Aged
  • Alcohol Amnestic Disorder
  • Auditory Perception
  • Color Perception
  • Discrimination, Psychological
  • Homovanillic Acid
  • Humans
  • Hydroxyindoleacetic Acid
  • Methoxyhydroxyphenylglycol
  • Middle Aged
  • Smell
  • Visual Perception
  • Digital Object Identifier (doi)

    Pubmed Id

  • 2433640
  • Start Page

  • 831
  • End Page

  • 839
  • Volume

  • 24
  • Issue

  • 6