Long-lasting changes in regional brain amino acids and monoamines in recovered pyrithiamine treated rats.

Academic Article


  • Rats were subjected to a severe bout of thiamine deficiency induced by daily pyrithiamine + a thiamine deficient diet, reversed by thiamine administration and allowed to recover. Pyrithiamine treated animals demonstrated impaired retention of a 24 h recall of passive avoidance. Regional brain concentration of norepinephrine, dopamine, serotonin, 3,4-dihydroxyphenylacetic acid, 5-hydroxyindoleacetic acid, GABA, glutamate, aspartate, glutamine, and glycine were determined after 2 and 9 weeks of nutritional recovery. A significant increase in NE content of cerebellum from the pyrithiamine treated animals was observed at both 2 and 9 week recovery periods. The concentrations of serotonin and its metabolite were significantly elevated in midbrain-thalamus and striatum. Significant reductions of GABA and glutamate were also observed in midbrain-thalamus. Amino acid levels in all other brain areas were unchanged from pair-fed controls. These results suggest regionally specific, chronic alterations in GABA, glutamate, serotonin, and norepinephrine activity following recovery from an acute bout of pyrithiamine-induced thiamine deficiency. The absence of a permanent reduction of cortical norepinephrine similar to that observed in an earlier study is discussed.
  • Authors

  • Langlais, PJ
  • Mair, Robert
  • Anderson, CD
  • McEntee, WJ
  • Status

    Publication Date

  • December 1988
  • Published In


  • Amino Acids
  • Animals
  • Biogenic Monoamines
  • Brain Chemistry
  • Chromatography, High Pressure Liquid
  • Male
  • Pyridinium Compounds
  • Pyrithiamine
  • Rats
  • Thiamine Deficiency
  • Digital Object Identifier (doi)

    Pubmed Id

  • 3237312
  • Start Page

  • 1199
  • End Page

  • 1206
  • Volume

  • 13
  • Issue

  • 12