MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats.

Academic Article


  • Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task and assigned by block randomization to one of four treatments: pyrithiamine-induced thiamine deficiency (PTD), PTD with administration of MK-801 after 12 days, control with MK-801 treatment, and control without MK-801. After 15 days of treatment followed by 21 days of recovery, the PTD rats showed significant deficits for DNMTS accuracy at retention intervals (RI) that ranged from 3.0 s to 15.0 s, the RIs that produced 75% accuracy on DNMTS in staircase training, and the rate at which a novel radial arm maze task was learned. The PTD-treated rats had consistent lesions in the thalamus and the mammillary bodies. MK-801 protected rats from both behavioral deficits and brain lesions (assessed quantitatively and qualitatively) that were produced by the PTD treatment.
  • Authors

  • Robinson, JK
  • Mair, Robert
  • Status

    Publication Date

  • August 1992
  • Published In


  • Alcohol Amnestic Disorder
  • Animals
  • Appetitive Behavior
  • Brain Mapping
  • Discrimination Learning
  • Dizocilpine Maleate
  • Male
  • Mental Recall
  • Orientation
  • Pyrithiamine
  • Rats
  • Reaction Time
  • Receptors, N-Methyl-D-Aspartate
  • Retention, Psychology
  • Thalamus
  • Thiamine Deficiency
  • Wernicke Encephalopathy
  • Digital Object Identifier (doi)

    Pubmed Id

  • 1386989
  • Start Page

  • 623
  • End Page

  • 633
  • Volume

  • 106
  • Issue

  • 4