Metastable supramolecular polymer nanoparticles via intramolecular collapse of single polymer chains.

Academic Article


  • We present an elegant approach for fabricating polymeric nanoparticles via the reversible noncovalent intramolecular cross-linking of single polymer chains. By protecting the well-studied 2-ureido-pyrimidinone moiety with an o-nitrobenzyl group, we have introduced a latent quadruple hydrogen bonding motif. Incorporating this group into linear poly(norbornenes) creates a class of supramolecular materials that can be readily dissolved and subsequently cross-linked upon irradiation with UV light, eliminating the need for selective solvent techniques. This is a facile method for producing well-defined particles with narrow polydispersity as confirmed by atomic force microscopy. By virtue of the nature of the intramolecular cross-linking (supramolecular interactions of pendant groups), these metastable nanoparticles are akin to folded biomacromolecules, representing the first step in linking synthetic polymers and self-folded biopolymers.
  • Authors

  • Foster, E Johan
  • Berda, Erik
  • Meijer, EW
  • Status

    Publication Date

  • May 27, 2009
  • Has Subject Area


  • Bioengineering
  • Nanotechnology
  • Digital Object Identifier (doi)

    Pubmed Id

  • 19405473
  • Start Page

  • 6964
  • End Page

  • 6966
  • Volume

  • 131
  • Issue

  • 20