Solving complex sustainability problems requires novel, creative approaches. One such approach is knowledge co-production, where individuals with diverse expertise collaborate to generate knowledge in support of transformative solutions. Although the concept is not new, there is growing interest in using knowledge co-production in sustainability science, yet relatively few resources offer a practical guide, rooted in theory, to help researchers and practitioners understand when and how to co-produce in the context of sustainability science. This paper synthesizes the existing literature across multiple disciplines to present a novel framework and actionable strategies for effective knowledge co-production in sustainability. The wheel of knowledge co-production, the conceptual framework presented, emphasizes the importance of iterative phases of building relationships, assessing available resources, involving diverse participants, considering context, and working together with partners to design mutually beneficial and respectful processes and outcomes.