Intra-chain photodimerization of pendant anthracene units as an efficient route to single-chain nanoparticle fabrication.

Academic Article


  • An efficient route to architecturally defined, sub-20 nm soft nanoparticles fabricated from single polymer chains via intramolecular photodimerization of pendant anthracene units is presented. Photodimerization is confirmed by the disappearance of the characteristic anthracene π-π* absorption peak at ≈ 360 nm measured by UV-vis spectroscopy. Size exclusion chromatography (SEC) with UV, multi-angle light scattering (MALS), and viscometric detection confirms that as photodimers form, the chains fold to form nanoparticles, demonstrated by shifts in the SEC traces to longer retention times as a function of increased irradiation time. These shifts indicate a reduction in hydrodynamic radius, corroborated and quantified by viscometric data. MALS detector traces reveal the presence of a small amount of chain-chain coupling during this process, but confirm that this is primarily a single-chain phenomenon. Electron microscopy provides visual confirmation of nanoparticle formation.
  • Authors

  • Frank, Peter G
  • Tuten, Bryan T
  • Prasher, Alka
  • Chao, Danming
  • Berda, Erik
  • Status

    Publication Date

  • January 2014
  • Published In


  • Anthracenes
  • Chromatography, Gel
  • Dimerization
  • Microscopy, Electron, Transmission
  • Nanoparticles
  • Photochemistry
  • SEC
  • Spectrophotometry, Ultraviolet
  • TEM
  • Viscosity
  • nanoparticles
  • photochemistry
  • polymer folding
  • Digital Object Identifier (doi)

    Pubmed Id

  • 24436174
  • Start Page

  • 249
  • End Page

  • 253
  • Volume

  • 35
  • Issue

  • 2