The Center for Mental Health Research and Innovation in Treatment Engagement and Service (MH-RITES Center) at the Graduate College of Social Work, University of Houston is an international multidisciplinary research center focused on improving treatment engagement and outcomes for those experiencing mental health concerns. Established in 2017, the mission of the MH-RITES Center is to drive empirically supported and evidence-based innovation that achieves optimal treatment access and engagement in mental health services by individuals and families who need them, specifically in historically marginalized communities. This article describes the history and guiding principles, organizational structure, funding sources, and physical resources of the MH-RITES Center while highlighting completed, ongoing, and future projects supporting the Center's mission.