Despite the decline in AIDS-related deaths worldwide, the consequence of the disease continues to be felt. This is exemplified in the unprecedented numbers of adult deaths and inability of the extended family to cope. These factors have impacted the welfare of children negatively. Focusing specifically on sub-Saharan Africa, a region severely struck by the pandemic, we examine the effects of the label ‘Orphan and Vulnerable Children’ (OVC), which has been utilized to identify children affected by HIV/AIDS, on the welfare of the affected children. Implications for policy, practice, and scholarship are suggested.