BACKGROUND: People's work life and career can ultimately be deconstructed to the day-to-day job tasks they perform, the people they interact with, and the value and meaning attached to their jobs. Individuals with work limitations and disabilities consistently experience disparities in the workplace resulting in a less than optimal work experience in all three areas. OBJECTIVE: The purpose of this study is to conduct a pilot study to test the effectiveness of job crafting as an occupational therapy (OT) intervention strategy for workers with health conditions and impairments. Job crafting is a proactive, strengths-based, bottom-up approach where workers renegotiate and redefine their job tasks in a personally meaningful way. METHODS: A mixed-methods study (n = 11) was conducted with workers who experience work limitations and disabilities. OT graduate students conducted in-depth interviews and facilitated the use of job crafting to improve work-related outcomes. Pre-and post-intervention data was analyzed using descriptive statistics and Wilcoxon signed-rank tests. Qualitative data was transcribed, coded, and synthesized. RESULTS: The job crafting intervention improved work-related self-efficacy (p < 0.05) and crafting behaviors (p < 0.05) in the workplace. Participants accomplished goals to manage their work limitations, meet job demands, and other non-disability related challenges. CONCLUSIONS: Job crafting has the potential to be used as a holistic OT intervention strategy to improve work-related self-efficacy among workers with work limitations and disabilities.