Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors

Academic Article

Abstract

  • Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.
  • Authors

  • Berrios, Christian
  • Jung, Joonil
  • Primi, Blake
  • Wang, Michael
  • Pedamallu, Chandrasekhar
  • Duke, Fujiko
  • Marcelus, Christina
  • Cheng, Jingwei
  • Garcea, Robert L
  • Meyerson, Matthew
  • DeCaprio, James A
  • Status

    Publication Date

  • January 1, 2015
  • Has Subject Area

    Published In

    Keywords

  • Adolescent Adult Aged Aged, 80 and over Antigens, Viral, Tumor/*metabolism Child Child, Preschool DNA, Viral/chemistry/genetics Female *Host-Pathogen Interactions Humans Infant Male Middle Aged Molecular Sequence Data Polyomavirus/*physiology Polyomavirus Infections/*epidemiology/virology Protein Binding Sequence Analysis, DNA Seroepidemiologic Studies Tumor Suppressor Proteins/*metabolism Young Adult
  • Digital Object Identifier (doi)

    Start Page

  • 857
  • End Page

  • 862
  • Volume

  • 89
  • Issue

  • 1