Reusable Cyclodextrin-Based Electrochemical Platform for Detection of trans-Resveratrol.

Academic Article


  • A reusable sensor architecture, through the combination of self-assembled monolayers and cyclodextrin supramolecular interactions, is demonstrated for class recognition of hydrophobic analytes demonstrated with trans-resveratrol. The reloadable sensor is based on reversible immobilization of α-cyclodextrin on polyethylene glycol surface. α-cyclodextrins complexes with polyethylene glycols and causes the polymer chains to change their surface configuration. The reproducibility and stability of the sur-face, in the detection of nanomolar concentrations of trans-resveratrol, can be demonstrated by electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and Attenuated total reflectance-Fourier transform infrared spectroscopy. We propose that during sensor operation, α-cyclodextrin decouples from the poly-ethylene glycol surface to complex with trans-resveratrol in solution, and after use, the surface regeneration is conducted with a simple α-cyclodextrin soak. To test the nonspecific response, the sensor was also tested with trans-resveratrol spiked human urine.
  • Authors

  • Panahi, Zahra
  • Merrill, Mckenna A
  • Halpern, Jeffrey
  • Status

    Publication Date

  • November 13, 2020
  • Published In


  • biosensor
  • cyclodextrin (CD)
  • electrochemical impedance spectroscopy (EIS)
  • hydrophobic analytes
  • resveratrol
  • Digital Object Identifier (doi)

    Start Page

  • 5086
  • End Page

  • 5093
  • Volume

  • 2
  • Issue

  • 11