Highly tunable bioadhesion and optics of 3D printable PNIPAm/cellulose nanofibrils hydrogels.

Academic Article


  • A hybrid poly(N-isopropylacrylamide) (PNIPAm)/cellulose nanofibrils (CNFs) hydrogel composite was fabricated by inverted stereolithography 3D printing to provide a new platform for regulating lower critical solution temperature (LCST) properties and thus tuning optical and bioadhesive properties. The phenomena of interest in the as-printed PNIPAm/CNF hydrogels may be attributed to the fiber-reinforced composite system between crosslinked PNIPAm and CNFs. The optical tunability was found to be correlated to the micro/nano structures of the PNIPAm/CNF hydrogel films. It was found that PNIPAm/CNF hydrogels exhibit switchable bioadhesivity to bacteria in response to CNF distribution in the hydrogels. After 2.0 wt% CNF was incorporated, it was found that a remarkable 8°C reduction of the LCST was achieved relative to PNIPAm hydrogel crosslinked by TEGDMA without CNF. The prepared PNIPAm/CNF hydrogels possessed highly reversible optical, bioadhesion, and thermal performance, making them suitable to be used as durable temperature-sensitive sensors and functional biomedical devices.
  • Authors

  • Sun, Xiaohang
  • Tyagi, Preeti
  • Agate, Sachin
  • McCord, Marian
  • Lucia, Lucian A
  • Pal, Lokendra
  • Status

    Publication Date

  • April 15, 2020
  • Published In


  • 3D printing
  • Acrylic Resins
  • Adhesives
  • Cellulose
  • Cellulose nanofibrils (CNFs)
  • Hydrogels
  • Inverted stereolithography
  • Nanofibers
  • Optics and Photonics
  • Particle Size
  • Poly(N-isopropylacrylamide) (PNIPAm)
  • Printing, Three-Dimensional
  • Stimuli-responsive materials
  • Surface Properties
  • Switchable bioadhesion
  • Tunable transparency
  • Digital Object Identifier (doi)

    Pubmed Id

  • 32070518
  • Start Page

  • 115898
  • Volume

  • 234