This mini review investigates the relationship and interactions of polymers under an applied electric field (AEF) for sensor applications. Understanding how and why polymers are reoriented and manipulated by under an AEF is essential for future growth in polymer-based electrochemical sensors. Examples of polymers that can be manipulated in an AEF for sensor applications are provided. Current methods of monitoring polymer reorientation will be described, but new techniques are needed characterize polymer response to various AEF stimuli. The unique and reproducible stimuli response of polymers elicited by an AEF has significant potential for growth in the sensing community.