Aging can significantly affect the viscoelastic properties and cracking behavior of asphalt mixtures, causing increase in stiffness, reduction in relaxation capability, and increase in brittleness. Eleven mixtures are evaluated using different laboratory conditioning protocols to evaluate how the properties of asphalt mixtures, including viscoelastic properties, fatigue, and fracture behavior will change over time. Comparisons between different aging levels and mixtures are conducted by using complex modulus (E*) (field cores are included), simplified viscoelastic continuum damage (S-VECD) approach, semi-circular bending (SCB), and disk shaped compact tension (DCT) fracture tests. The climatic aging index developed by the NCHRP 09-54 project is utilized in this study to calculate the appropriate field aging duration corresponding to the different laboratory aging protocols. Pavement evaluation tools FlexPAVETM and IlliTC are also used to predict and compare the fatigue and thermal cracking performance of these mixtures. The results of E* and S-VECD tests indicate that the mixtures are more prone to fatigue cracking with aging, and the two long-term conditioning protocols induce statistically similar changes in linear viscoelastic and fatigue properties. However, prediction of fatigue performance from FlexPAVE TM does not show a consistent trend once pavement structure and traffic are considered. Fracture tests and IlliTC predictions show the virgin mixtures and those with soft base binders will have better capability to resist cracking after long-term aging. In this study, the two mixtures with the largest difference between high and low temperature performance grade (PG) show the largest change in fracture and fatigue properties with aging.