AbstractThis article highlights the rise and geographic spread of depopulation in rural America over the past century. “Depopulation” refers to chronic population losses that prevent counties from returning to an earlier period of peak population size. In this article, we identify 746 depopulating counties—mostly nonmetropolitan—representing 24 percent of all U.S. counties. More than 46 percent of remote rural counties are depopulating compared to 24 percent of the adjacent nonmetropolitan counties and just 6 percent of metropolitan counties. Rural county populations often peaked in size during the 1940s and 1950s, especially in the agricultural heartland. Depopulation today reflects a complex interplay of chronic net out‐migration and natural decrease that is rooted in the past. Depopulation not only is a direct result of persistent out‐migration but also reflects large second‐order effects expressed in declining fertility and rising mortality (usually associated with population aging). Depopulation has become a signature demographic phenomenon in broad regions of rural America.