PALADIN:Protein Alignment for Functional Profiling Whole Metagenome Shotgun Data

Academic Article


  • Whole metagenome shotgun sequencing is a powerful approach for assaying the functional potential of microbial communities. Presently, we lack tools that efficiently and accurately align DNA reads against protein references, the technique necessary for constructing a functional profile. Here, we present PALADIN—a novel modification of Burrows-Wheeler Aligner that provides more accurate alignment and orders-of-magnitude improved efficiency by directly mapping in protein space.
  • Authors

  • Westbrook, Anthony
  • Ramsdell, Jordan
  • Aggarwal, Taruna
  • Normington, Louisa
  • Bergeron, Daniel
  • Thomas, Kelley
  • MacManes, Matthew
  • Status

    Publication Date

  • 2016
  • Digital Object Identifier (doi)