Combinatorial Efficacy of Quercitin and Nanoliposomal Ceramide for Acute Myeloid Leukemia.

Academic Article

Abstract

  • Acute myeloid leukemia (AML) is an aggressive hematological malignancy with limited treatment options. Inflammation is often a contributing factor to the development and progression of AML, and related diseases, and can potentiate therapy failure. Previously, we had identified anti-inflammatory roles and anti-AML efficacy for blueberry extracts. The present study extended these observations to determine that the polyphenol quercetin inhibited neutral sphingomyelinase (N-SMase) activity and exerted anti-AML efficacy. Moreover, quercetin was shown to exert combinatorial anti-AML efficacy with nanoliposomal ceramide. Overall, this demonstrated that quercetin could block the pro-inflammatory actions of N-SMase and augment the efficacy of anti-AML therapeutics, including ceramide-based therapeutics.
  • Authors

  • McGill, Colin M
  • Brown, Timothy J
  • Fisher, Lindsey N
  • Gustafson, Sally J
  • Dunlap, Kriya L
  • Beck, Adam J
  • Toran, Paul T
  • Claxton, David F
  • Barth, Brian
  • Status

    Publication Date

  • 2018
  • Published In

  • Int J Biopharm Sci  Journal
  • Keywords

  • acute myeloid leukemia
  • blueberry
  • nanoliposomal ceramide
  • neutral sphingomyelinase
  • quercetin
  • Digital Object Identifier (doi)

    Start Page

  • 106
  • End Page

  • 106
  • Volume

  • 1
  • Issue

  • 1