Messenger functions of the bacterial cell wall-derived muropeptides.

Academic Article


  • Bacterial muropeptides are soluble peptidoglycan structures central to recycling of the bacterial cell wall and messengers in diverse cell signaling events. Bacteria sense muropeptides as signals that antibiotics targeting cell-wall biosynthesis are present, and eukaryotes detect muropeptides during the innate immune response to bacterial infection. This review summarizes the roles of bacterial muropeptides as messengers, with a special emphasis on bacterial muropeptide structures and the relationship of structure to the biochemical events that the muropeptides elicit. Muropeptide sensing and recycling in both Gram-positive and Gram-negative bacteria are discussed, followed by muropeptide sensing by eukaryotes as a crucial event in the innate immune response of insects (via peptidoglycan-recognition proteins) and mammals (through Nod-like receptors) to bacterial invasion.
  • Authors

  • Boudreau, Marc
  • Fisher, Jed F
  • Mobashery, Shahriar
  • Status

    Publication Date

  • April 10, 2012
  • Published In

  • Biochemistry  Journal
  • Keywords

  • Bacterial Proteins
  • Carrier Proteins
  • Cell Wall
  • Gram-Negative Bacteria
  • Host-Pathogen Interactions
  • Immunity, Innate
  • Peptidoglycan
  • Digital Object Identifier (doi)

    Start Page

  • 2974
  • End Page

  • 2990
  • Volume

  • 51
  • Issue

  • 14