Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates.

Academic Article

Abstract

  • A series of nucleotide analogues wherein the diphosphate moiety has been replaced by a dicarboxylate were synthesized and tested for inhibitory activity against nucleoside diphosphate (NDP) kinase as well as several pathogenic bacterial strains.

    • Authors

  • Boudreau, Marc
  • Vederas, John C

    • Status

    Publication Date

  • February 21, 2007

    • Has Subject Area

    Published In

    Keywords

  • Biomimetic Materials
  • Dicarboxylic Acids
  • Diphosphates
  • Enzyme Activation
  • Enzyme Inhibitors
  • Models, Molecular
  • Molecular Structure
  • Nucleoside-Diphosphate Kinase
  • Nucleosides
  • Stereoisomerism
  • Structure-Activity Relationship

    • Digital Object Identifier (doi)

    Pubmed Id

  • 17285171

    • Start Page

  • 627

    • End Page

  • 635

    • Volume

  • 5

    • Issue

  • 4