Although persons with disabilities are underrepresented in the workforce, a substantial portion of adults with disabilities does work. Job satisfaction, an important predictor of productivity, job tenure, and absenteeism, may be influenced by a unique set of personal and organizational factors for persons with disabilities. Using data from the 2015 Kessler Foundation National Employment and Disability Survey (KFNEDS), we examine personal and organizational predictors of job satisfaction for American workers with disabilities. Findings from the study suggest that educational attainment, perceived pay disparities, and supervisor attitudes are associated with job satisfaction for workers with disabilities. Coworker attitudes were not associated with job satisfaction for this population.