Motion-induced blindness describes the disappearance of stationary elements of a scene when other, perhaps non-overlapping, elements of the scene are in motion. We measured the effects of increment (200.0 cd/m2) and decrement targets (15.0 cd/m2) and masks presented on a grey background (108.0 cd/m2), tapping into putative ON- and OFF-channels, on the rate of target disappearance psychophysically. We presented two-frame motion, which has coherent motion energy, and dynamic Glass patterns and dynamic anti-Glass patterns, which do not have coherent motion energy. Using the method of constant stimuli, participants viewed stimuli of varying durations (3.1 s, 4.6 s, 7.0 s, 11 s, or 16 s) in a given trial and then indicated whether or not the targets vanished during that trial. Psychometric function midpoints were used to define absolute threshold mask duration for the disappearance of the target. 95% confidence intervals for threshold disappearance times were estimated using a bootstrap technique for each of the participants across two experiments. Decrement masks were more effective than increment masks with increment targets. Increment targets were easier to mask than decrement targets. Distinct mask pattern types had no effect, suggesting that perceived coherence contributes to the effectiveness of the mask. The ON/OFF dichotomy clearly carries its influence to the level of perceived motion coherence. Further, the asymmetry in the effects of increment and decrement masks on increment and decrement targets might lead one to speculate that they reflect the ‘importance’ of detecting decrements in the environment.