Molecularly imprinted polymers for the selective detection of multi-analyte neurotransmitters

Academic Article

Abstract

  • This paper reports on the development of electrochemical sensors for the detection of multiple neurotransmitters using molecularly imprinted polymers (MIPs). Pyrrole (PPy) and o-phenylenediamine (o-PD) were used as functional monomers for the MIP sensor development, and the characteristics of those sensors were analyzed. Specifically, we demonstrate a selective detection of dopamine (DA), norepinephrine (NE), and epinephrine (EP) by applying differential pulse voltammetry (DPV) to each uniquely developed MIP-based sensor. Furthermore, the selectivity of the analyte was quantified based on the sensitivity matrix. Our results demonstrate that all MIP sensors possessed higher sensitivity than non-imprinted (NIP) sensors due to the unique molecular receptors. The detection limits of the developed MIP sensors were less than 1.3 × 10− 5M. The uniqueness of the cross-reactivity in the DA-imprinted and EP-imprinted sensors demonstrate the possibility of implementing a multi-analyte sensing platform that can detect multiple neurotransmitters simultaneously from a single sample solution.
  • Authors

  • Si, Bo
  • Song, Edward
  • Status

    Publication Date

  • February 5, 2018
  • Has Subject Area

    Published In

    Keywords

  • Conducting polymers
  • Differential pulse voltammetry
  • Molecular imprinting
  • Neurotransmitters
  • Polypyrrole
  • o-Phenylenediamine
  • Digital Object Identifier (doi)

    Start Page

  • 58
  • End Page

  • 65
  • Volume

  • 187
  • Issue

  • Neuron 68 2010