Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.

Academic Article


  • The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain overexpressing AC1 in the forebrain. Here we report that AC1+ mice exhibit hyperactive behaviors and demonstrate increased impulsivity and reduced sociability. In contrast, AC1 and AC8 double knock-out mice are hypoactive, and exhibit increased sociability and reduced impulsivity. Interestingly, the hyperactivity of AC1+ mice can be corrected by valproate, a mood-stabilizing drug. These data indicate that increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition.
  • Authors

  • Chen, Xuanmao
  • Cao, Hong
  • Saraf, Amit
  • Zweifel, Larry S
  • Storm, Daniel R
  • Status

    Publication Date

  • January 7, 2015
  • Published In


  • ADHD
  • Adenylyl Cyclases
  • Animals
  • Gene Expression Regulation, Enzymologic
  • Inhibition, Psychological
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Prepulse Inhibition
  • Prosencephalon
  • Random Allocation
  • behavioral inhibition
  • hyperactivity
  • impulsivity
  • sociability
  • type I adenylyl cyclase
  • Digital Object Identifier (doi)

    Start Page

  • 339
  • End Page

  • 351
  • Volume

  • 35
  • Issue

  • 1