A series of dynamic centrifuge experiments involving a soil-structure model were performed to investigate the influence of ground motion characteristics on site performance and soil-foundation-structure interaction (SFSI) on medium-dense sand. When investigating kinematic SFSI, the translational component of the foundation motion was observed to de-amplify compared to the free-field in terms of most intensity parameters primarily during intense shaking and at higher frequencies. The building's fundamental rocking frequency was strongly influenced by the predominant frequency of the base motion. When investigating inertial SFSI, increasing the shaking intensity was observed to increase the flexible-base natural period of the structure. Spectral accelerations at the foundation level were significantly amplified near the building's flexible-base natural period. Structural settlements were greater than those in the free-field, and their rate followed the rate of the Arias intensity time history of the base motion. More holistic ground motion parameters, such as Arias and Housner Intensities, demonstrated a strong and consistent influence on SFSI and site performance.