Shifting constraints on tRNA genes during mitochondrial DNA evolution in animals.

Academic Article

Abstract

  • During the evolution of echinoderm mitochondrial (mt) DNA, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. To examine the evolutionary consequences of this event, we sequenced 961 bp of mtDNA in five sea urchin species. This enabled us to build a tree relating the mtDNAs and use it for analyzing the pattern and process of evolutionary substitutions in the former leucine tRNA gene, which now is a 5' extension of the gene for NADH dehydrogenase subunit 5 (ND5). This 5' extension is now evolving at the same rate and under the same protein-coding constraints as the rest of ND5. The adjacent (upstream) serine tRNA gene, however, has been evolving at a reduced rate, consistent with the possibility that it has assumed a punctuation role in processing of the primary transcript that was once fulfilled by the former leucine tRNA gene.
  • Authors

  • Thomas, William
  • Maa, J
  • Wilson, AC
  • Status

    Publication Date

  • October 1989
  • Published In

  • New Biol  Journal
  • Keywords

  • Animals
  • Base Sequence
  • Biological Evolution
  • DNA, Mitochondrial
  • Genes
  • Genetic Variation
  • Molecular Sequence Data
  • NADH Dehydrogenase
  • Phylogeny
  • RNA Processing, Post-Transcriptional
  • RNA, Transfer
  • RNA, Transfer, Leu
  • RNA, Transfer, Ser
  • Regulatory Sequences, Nucleic Acid
  • Sea Urchins
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Pubmed Id

  • 2488275
  • Start Page

  • 93
  • End Page

  • 100
  • Volume

  • 1
  • Issue

  • 1