Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model.

Academic Article

Abstract

  • Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers of a perfect 82-bp direct repeat. We propose a model for the replicative origin of length differences, involving a competitive equilibrium between the heavy strand and the D-loop strand. This model suggests that frequent misalignment in the repeat region prior to elongation, facilitated by a stable secondary structure in the displaced strand, can explain both the polymorphism and heteroplasmy in this species.
  • Authors

  • Buroker, NE
  • Brown, JR
  • Gilbert, TA
  • O'Hara, PJ
  • Beckenbach, AT
  • Thomas, W. Kelley
  • Smith, MJ
  • Status

    Publication Date

  • January 1990
  • Published In

  • Genetics  Journal
  • Keywords

  • Animals
  • Base Sequence
  • DNA Replication
  • DNA, Mitochondrial
  • Fishes
  • Models, Genetic
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Polymorphism, Restriction Fragment Length
  • Repetitive Sequences, Nucleic Acid
  • Start Page

  • 157
  • End Page

  • 163
  • Volume

  • 124
  • Issue

  • 1