Corticosterone: a critical factor in an opioid form of stress-induced analgesia.

Academic Article

Abstract

  • The finding that some opioid-mediated forms of stress-induced analgesia are antagonized by hypophysectomy and dexamethasone has led to the suggestion that beta-endorphin, released from the pituitary, may mediate these analgesic reactions. "Long-term analgesia" (an opioid-mediated form of stress-induced analgesia), which is blocked by dexamethasone and hypophysectomy, was also blocked by adrenalectomy and reinstated with corticosterone therapy. Corticosterone is proposed to play a permissive role in long-term analgesia and to be a critical hormone mediating this phenomenon.
  • Authors

  • MacLennan, AJ
  • Drugan, Robert
  • Hyson, RL
  • Maier, SF
  • Madden, J
  • Barchas, JD
  • Status

    Publication Date

  • March 19, 1982
  • Published In

    Keywords

  • Adrenalectomy
  • Analgesia
  • Animals
  • Corticosterone
  • Dexamethasone
  • Endorphins
  • Hypophysectomy
  • Pain
  • Rats
  • Stress, Physiological
  • Digital Object Identifier (doi)

    Pubmed Id

  • 7063862
  • Start Page

  • 1530
  • End Page

  • 1532
  • Volume

  • 215
  • Issue

  • 4539