Coping and immunosuppression: inescapable but not escapable shock suppresses lymphocyte proliferation.

Academic Article

Abstract

  • Rats were given series of escapable shocks, identical inescapable shocks, or no shock. The subjects were reexposed to a small amount of shock 24 hours later, after which an in vitro measure of the cellular immune response was examined. Lymphocyte proliferation in response to the mitogens phytohemagglutinin and concanavalin A was suppressed in the inescapable shock group but not in the escapable shock group. This suggests that the controllability of stressors is critical in modulating immune functioning.
  • Authors

  • Laudenslager, ML
  • Ryan, SM
  • Drugan, Robert
  • Hyson, RL
  • Maier, SF
  • Status

    Publication Date

  • August 5, 1983
  • Published In

    Keywords

  • Animals
  • Concanavalin A
  • Electroshock
  • Humans
  • Immune Tolerance
  • Immunity, Cellular
  • Lymphocytes
  • Phytohemagglutinins
  • Rats
  • Stress, Psychological
  • T-Lymphocytes
  • Digital Object Identifier (doi)

    Pubmed Id

  • 6603018
  • Start Page

  • 568
  • End Page

  • 570
  • Volume

  • 221
  • Issue

  • 4610