Positions

Overview

  • Research Interests

    Our lab utilizes organic chemistry and chemical biology to study antibiotic resistance in bacteria. Organic synthesis is used to access new compounds that either exhibit unexplored mechanisms of inhibition against known bacterial targets, or that can function as probes for the identification of new targets. The synthesized compounds are evaluated in-house against clinically relevant bacterial strains and against their proposed enzyme targets. The mechanism of inhibition of active compounds is studied in detail, which is then utilized to inform the rational design of improved inhibitors.
  • Publications

    Academic Article

    Year Title
    2016 Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry.ACS Nano.  10:8843-8850. 2016
    2016 Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.Bioorganic and Medicinal Chemistry Letters.  26:1011-1015. 2016
    2015 Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.Bioorganic and Medicinal Chemistry Letters.  25:4854-4857. 2015
    2015 Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules.ACS Infectious Diseases.  1:454-459. 2015
    2015 Structure-activity relationship for the oxadiazole class of antibiotics.Journal of Medicinal Chemistry Journal of Medicinal and Pharmaceutical Chemistry.  58:1380-1389. 2015
    2014 Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.Journal of the American Chemical Society.  136:3664-3672. 2014
    2012 Messenger functions of the bacterial cell wall-derived muropeptides.Biochemistry.  51:2974-2990. 2012
    2010 Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity.Journal of the American Chemical Society.  132:1486-1487. 2010
    2009 A new proposal concerning the botanical origin of Baltic amber.Proceedings of the Royal Society B: Biological Sciences.  276:3403-3412. 2009
    2009 Retention of configuration in photolytic decarboxylation of peresters to form chiral acetals and ethers.Organic Letters.  11:645-648. 2009
    2008 Hydrophobic interactions as substitutes for a conserved disulfide linkage in the type IIa bacteriocins, leucocin A and pediocin PA-1.ChemBioChem.  9:1898-1901. 2008
    2007 Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates.Organic and Biomolecular Chemistry Journal of the Chemical Society, Perkin Transactions 1.  5:627-635. 2007

    Conference Proceeding

    Year Title
    Adjuvant Strategies for Restoring β-Lactam Activity Against Antibiotic Resistant Bacteria
    Boudreau Group Research Overview
    Bringing β-lactam antibiotics back to life: Strategies for restoring their activity against resistant bacteria
    Modification at the Penam C6-Position for the Inhibition of Carbapenem-Hydrolyzing Class D β-Lactamases
    Strategies for Restoring β-Lactam Activity Against Antibiotic Resistant Bacteria
    Synthesis of analogues of nosokophic acid

    Teaching Activities

  • Adv Rsrch Exp/Chemistry Taught course 2019
  • Organic Chemistry Taught course 2018
  • Rsrch Exp/Chemistry Taught course 2018
  • Rsrch Exp/Chemistry Taught course 2018
  • Thesis Taught course 2018
  • Organic Chemistry Taught course 2017
  • Thesis Taught course 2017
  • Adv Rsrch Exp/Chemistry Taught course 2017
  • Rsrch Exp/Chemistry Taught course 2017
  • Thesis Taught course 2017
  • Adv Rsrch Exp/Chemistry Taught course 2016
  • Rsrch Exp/Chemistry Taught course 2016
  • Spectroscopic Inv Organc Molec Taught course 2016
  • Thesis Taught course 2016
  • Independent Study Taught course 2016
  • Rsrch Exp/Chemistry Taught course 2016
  • Synthetic Organic Chemistry I Taught course 2016
  • Sem/Organic-Inorganic Taught course 2015
  • Spectroscopic Inv Organc Molec Taught course 2015
  • Education And Training

    Full Name

  • Marc Boudreau