Positions

Research Areas research areas

Overview

  • Dr. Kyle MacLea is an Associate Professor of Biological Sciences and Biotechnology at UNH Manchester where he teaches courses in the areas of molecular biology and microbiology. His research interests include prions and amyloids in yeast and human disease, microbial genetics and genomics, particularly of bacteria and bacteriophages. In the past he has also studied the biology of molting and limb regeneration in decapod crustaceans (such as crabs, lobsters, and crayfish). A member of the Council on Undergraduate Research and the Genome Consortium for Active Teaching, Dr. MacLea is keenly interested in involving undergraduate biology students in authentic scientific research experiences, inside and outside of the classroom.
  • Publications

    Academic Article

    Year Title
    2019 Genome Sequence of the Radiation-Resistant Bacterium Deinococcus radiophilus ATCC 27603T.Microbiol Resour Announc.  8. 2019
    2019 Genome Sequence of the Moderately Halophilic Yellow Sea Bacterium Lentibacillus salicampi ATCC BAA-719T.Microbiol Resour Announc.  8. 2019
    2019 Draft Genome Sequence of Xanthobacter tagetidis ATCC 700314T.Microbiol Resour Announc.  8. 2019
    2018 Draft Genome Sequence of the Psychrotolerant Bacterium Kurthia sibirica ATCC 49154T.Microbiol Resour Announc.  7:e00841-e00818. 2018
    2018 Genome Sequence of Kurthia Type Species Kurthia zopfii Strain ATCC 33403T.Microbiol Resour Announc.  7:e00833-e00818. 2018
    2018 Genome Sequence of the Halophilic Bacterium Kangiella spongicola ATCC BAA-2076T.Microbiol Resour Announc.  7:e00847-e00818. 2018
    2018 Genome Sequences for Three Strains of Kocuria rosea, Including the Type Strain.Genome Announcements.  6:e00594-e00518. 2018
    2017 Complete Genome Sequence of Staphylococcus epidermidis ATCC 12228 Chromosome and Plasmids, Generated by Long-Read Sequencing.Genome Announcements.  5:e00954-e00917. 2017
    2017 Draft Genome Sequence of the Marine Bacterium Oceanimonas baumannii ATCC 700832T.Genome Announcements.  5:e01007-e01017. 2017
    2017 Genome Sequence of Oceanimonas doudoroffii ATCC 27123T.Genome Announcements.  5:e00996-e00917. 2017
    2017 Draft Genome Sequence of the Salt Water Bacterium Oceanospirillum linum ATCC 11336T.Genome Announcements.  5:e00395-e00317. 2017
    2017 Genome Sequence of a Marine Spirillum, Oceanospirillum multiglobuliferum ATCC 33336T, Isolated from Japan.Genome Announcements.  5:e00396-e00317. 2017
    2017 What Makes a Prion: Infectious Proteins From Animals to Yeast.International Review of Cell and Molecular Biology.  329:227-276. 2017
    2016 Roles of mechanistic target of rapamycin and transforming growth factor-β signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.  198:15-21. 2016
    2015 Draft Whole-Genome Sequence of the Marine Bacterium Idiomarina zobellii KMM 231T.Genome Announcements.  3:e01257-e01215. 2015
    2015 Genome Sequence of the Deep-Sea Bacterium Idiomarina abyssalis KMM 227T.Genome Announcements.  3:e01256-e01215. 2015
    2015 Distinct amino acid compositional requirements for formation and maintenance of the [PSI⁺] prion in yeast.Molecular and Cellular Biology.  35:899-911. 2015
    2014 Molt regulation in green and red color morphs of the crab Carcinus maenas: gene expression of molt-inhibiting hormone signaling components (vol 217, pg 796, 2014)Journal of Experimental Biology.  217:1830-1830. 2014
    2014 Molt regulation in green and red color morphs of the crab Carcinus maenas: gene expression of molt-inhibiting hormone signaling components.Journal of Experimental Biology.  217:796-808. 2014
    2014 Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.  168:25-39. 2014
    2013 Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.Nature Nature: New biology.  495:467-473. 2013
    2013 A bioinformatics method for identifying Q/N-rich prion-like domains in proteins.Methods in Molecular Biology.  1017:219-228. 2013
    2012 Breaking Through the Spiral Ceiling: An American Woman Becomes a DNA ScientistJournal of the History of Biology.  45:357-360. 2012
    2012 Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.Journal of Experimental Biology.  215:590-604. 2012
    2011 Strategies for identifying new prions in yeast.Prion.  5:263-268. 2011
    2010 Myostatin from the American lobster, Homarus americanus: Cloning and effects of molting on expression in skeletal muscles.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.  157:328-337. 2010
    2008 Using integrative genomics to elucidate genetic resistance to Marek's disease in chickens.Developments in Biologicals Developments in Biological Standardization.  132:365-372. 2008
    2007 The Threat of Marek's Disease Virus Is ExpandingMicrobe.  2:238-243. 2007
    2006 Cloning and expression of deoxyribonuclease II from chicken.Gene.  373:44-51. 2006
    2003 Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging.Biochemical Journal.  371:867-876. 2003
    2003 A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei.Gene.  305:1-12. 2003
    2002 Deoxyribonuclease IIalpha is required during the phagocytic phase of apoptosis and its loss causes perinatal lethality.Cell Death and Differentiation.  9:956-962. 2002
    2002 Revised structure of the active form of human deoxyribonuclease IIalpha.Biochemical and Biophysical Research Communications.  292:415-421. 2002
    2001 The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta.Gene.  269:205-216. 2001

    Conference Proceeding

    Year Title
    2014 Determining amino acid propensity for propagation of the prion Sup35 in Saccharomyces cerevisiaeFASEB Journal. 2014
    2014 Targeted mutagenesis of the oligopeptide repeat domain of the yeast prion Sup35FASEB Journal. 2014
    2012 Cloning and Characterization of a Novel Transforming Growth Factor-beta in CrustaceansIntegrative and Comparative Biology American Zoologist. E240-E240. 2012
    2012 Effects of molting on expression of FKBP12, an inhibitor of mTOR-regulated protein synthesis, in crustacean skeletal muscleIntegrative and Comparative Biology American Zoologist. E320-E320. 2012
    2011 Cloning and expression of mTOR signaling components in the Y-organ of decapod crustaceansIntegrative and Comparative Biology American Zoologist. E158-E158. 2011
    2011 Cloning of FKBP12, an inhibitor of mTOR-regulated protein synthesis, and its expression in crustacean skeletal muscleIntegrative and Comparative Biology American Zoologist. E244-E244. 2011
    2011 Effect of eyestalk ablation on expression of NO synthase and guanylyl cyclases in the Y-organ from green and red color morphs of Carcinus maenasIntegrative and Comparative Biology American Zoologist. E214-E214. 2011
    2011 Long-term effects of eyestalk ablation and multiple limb autotomy on myostatin expression in skeletal muscle of Carcinus maenas.Integrative and Comparative Biology American Zoologist. E215-E215. 2011
    2011 Molt inhibition by limb bud autotomy in the blackback land crab, Gecarcinus lateralis: effects on hemolymph ecdysteroid titers and expression of myostatin and R-Smad in skeletal muscleIntegrative and Comparative Biology American Zoologist. E178-E178. 2011
    2011 Rheb, an activator of the mTOR complex, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting on expression in skeletal muscleIntegrative and Comparative Biology American Zoologist. E237-E237. 2011
    2010 Cloning and Characterization of Guanylyl Cyclases from the European Green CrabIntegrative and Comparative Biology American Zoologist. E236-E236. 2010
    2004 Genomic and proteomic analyses of the vascular response to nicotineArteriosclerosis, Thrombosis, and Vascular Biology. E49-E49. 2004
    2004 Two-dimensional differential gel electrophoresis for proteomic expression analysis of vascular smooth muscle cells exposed to oxidant stressArteriosclerosis, Thrombosis, and Vascular Biology. E2-E2. 2004
    2001 Structure and processing of human deoxyribonuclease IIFASEB Journal. A202-A202. 2001

    Teaching Activities

  • Exploring Biology Teaching Taught course 2019
  • General Microbiology Taught course 2019
  • General Microbiology Lab Taught course 2019
  • IS/Exploring Dentistry Taught course 2019
  • Internship Taught course 2019
  • Research Taught course 2019
  • Microbial Genomics Taught course 2019
  • Microbial Genomics Lab Taught course 2019
  • Research Taught course 2019
  • Internship Taught course 2018 - 2019
  • Clinical Microbiol Internship Taught course 2018
  • General Microbiology Taught course 2018
  • Internship Taught course 2018
  • Research Taught course 2018
  • Internship Taught course 2018
  • Bacteriology of Food Taught course 2018
  • Bacteriology of Food Lab Taught course 2018
  • General Microbiology Taught course 2018
  • Internship Taught course 2018
  • Exploring Biology Teaching Taught course 2017
  • Internship Taught course 2017
  • Pathogenic Microbiology Taught course 2017
  • Pathogenic Microbiology Lab Taught course 2017
  • Research Taught course 2017
  • Internship Taught course 2017
  • Internship Taught course 2017
  • Microbial Genomics Taught course 2017
  • Microbial Genomics Lab Taught course 2017
  • Research Taught course 2017
  • Senior Seminar I Taught course 2017
  • The Business of Biotechnology Taught course 2017
  • Biomanufacturing Taught course 2016
  • Internship Taught course 2016
  • Research Taught course 2016
  • General Microbiology Taught course 2016
  • General Microbiology Lab 1 Taught course 2016
  • Principles of Biology I Taught course 2016
  • Internship Taught course 2016
  • Bacteriology of Food Taught course 2016
  • Bacteriology of Food Lab Taught course 2016
  • Internship Taught course 2016
  • Pathogenic Microbiology Taught course 2016
  • Research Taught course 2016
  • Internship Taught course 2015 - 2016
  • General Microbiology Taught course 2015
  • General Microbiology Lab 1 Taught course 2015
  • Nucleic Acid Techniques Taught course 2015
  • Principles of Biology I Taught course 2015
  • Microbial Genomics Taught course 2015
  • Molecular Genetics Taught course 2015
  • Pathogenic Microbiology Taught course 2015
  • Pathogenic Microbiology Lab 1 Taught course 2015
  • General Microbiology Taught course 2014
  • General Microbiology Lab 1 Taught course 2014
  • Principles of Biology I Taught course 2014
  • Education And Training

    Full Name

  • Kyle MacLea
  • Mailing Address

  • University of New Hampshire

    Department of Life Sciences

    88 Commercial St

    Manchester, New Hampshire  03101

    United States