Publication Venue For
Ineffective erythropoiesis of TET2 deficiency
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.
Identification of a gain-of-function STAT3 mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndrome.
Emerging EPO and EPO receptor regulators and signal transducers.
The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma.
Erythroid mRNA processing: a "splice of life".
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.
Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity.
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.
During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool.
Micro-mismanaging sickle cell stress.
Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells.
CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools.
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.
Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2.
EPO receptor circuits for primary erythroblast survival.
EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts.
Erythropoietin modulation of podocalyxin and a proposed erythroblast niche.
Lyn kinase promotes erythroblast expansion and late-stage development.
Selective activation of TACI by syndecan-2.
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia.
Core erythropoietin receptor signals for late erythroblast development.
Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.
Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells.
Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms.
mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development.
A minimal cytoplasmic subdomain of the erythropoietin receptor mediates erythroid and megakaryocytic cell development.
Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization.
Tumor cell cytotoxicity of a novel metal chelator.
Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells.
Hematopoietic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells.
Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters.
Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells.
Steel factor affects SCL expression during normal erythroid differentiation.
Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain.
BIOTINYLATED ERYTHROPOIETIN - REPLY
Biotinylated recombinant human erythropoietins: bioactivity and utility as receptor ligand.
High-level expression and purification of a recombinant human erythropoietin produced using a baculovirus vector.
Novel EPO/EPOR/JAK2 targets and signal transduction pathways revealed by phospho-PTM proteomic profiling
"C1ORF150", a Novel Mediator of EPO/EPOR/JAK2 Dependent Human Erythroid Progenitor Cell Formation
EPO Modulation of Thioredoxin Interacting Protein (TXNIP), and Key Roles for TXNIP during EPO-Dependent Human Erythroid Progenitor Cell Growth and Development
Podocalyxin Negatively Regulates Stress Myelopoiesis, Directly Binds Rap-1A and Modulates Its G-CSF-Induced Activity
A Novel Mechanism of GLI2 Mediated Regulation of IgM Secretion in Waldenstrom Macroglobulinemia
Discovery of Novel EPO/EPOR/JAK2 Targets and Signal Transduction Factors Via Proteomic-Based Interrogations of Post-Translational Motif Modifications
GLI Transcription Factors Modulate IgM Secretion In Waldenstrom Macroglobulinemia
Ligand-Regulated and Developmental Stage-Specific Expression Of The EPO Receptor During Human Erythroid Progenitor Cell Formation
The Human Platelet Glycome and Its Variations Among Healthy Volunteers and Storage
The Transcription Factor GLI3 Is a Novel Candidate Effector Of Toll-Like Receptor 4 (TLR4) Signaling In Monocytes
Trib2 Pseudokinase Marks Early CMP Progenitors, and Promotes Granulocytic Plus Erythroid Progenitor Cell Formation
Erythropoietin-Directed Erythropoiesis Depends Upon Serpin Inhibition of Erythroblast Lysosomal Cathepsins
Hematopoietic Lineage Selective Roles for Trib Pseudokinases Post Bone Marrow Transplantation
The Erythropoiesis Stimulating Agent Omontys/Peginesatide up-Modulates Erythroid Progenitor Formation, and Cell Surface Erythropoietin Receptor Levels
"RHEX-26", a Novel EPO/EPOR-Regulated Mediator of Human Erythroid Progenitor Cell Expansion
Dynamic Erythropoietin Receptor Trafficking Within Cell Surface, and Intracellular Pools
Epo Engages a Tnfr-13c Pathway to Advance for Primary Bone Marrow (Pro)Erythroblast Development
GLI2, An Effector of the Hedgehog Pathway, Is a Novel Regulator of IL6 Oncogenic Function In the Tumor Microenvironment
BMP Signaling Is Crucial for Regulation Vascular Progenitor Development in Human Embryonic Stem Cells.
Inhibition of the Jak/Stat Pathway Downregulates Immunoglobulin Production and Induces Cell Death in Waldenstrom Macroglobulinemia.
Spry1 Plays Selective Hematopoietic Roles as An Erythropoietin - Modulated Positive Regulator of Erythropoiesis
TRIB3 Pseudokinase Is Induced Via An EPO/EPOR/STAT5 Pathway, Markedly up-Modulated in Late-Stage Erythroblasts, and Plays An Essential Non-Redundant Role During Stress Erythropoiesis
Comprehensive Analysis of the Waldenstrom Macroglobulinemia "Cytokine Milieu" Reveals a Novel Role of Rantes Signaling in the Regulation of Immunoglobulin Production
Monocytes Promote Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma and Are Recruited to the Tumor Microenvironment by CCL5
Non-Redundant Roles for an Epo/EpoR/STAT5 Regulated Intracellular Serpin, Serpina-3G, during Epo- and Anemia- Induced Erythropoiesis
miRNA Analysis Identifies a Unique Expression in Waldenstrom Macroglobulinemia B Cells and Plasma Cells
GSK626616: A DYRK3 inhibitor as a potential new therapy for the treatment of anemia
Multiplex analysis of serum cytokine levels in Waldenstrom macroglobulinemia patients
Epo modulation of cell cycle regulatory genes via PY343/STAT5 and PI3K pathways in primary erythroblasts.
Epo receptor circuits to Irs2, Foxo3a, Trb3 and Bim 1 expression, and erythroblast survival.
Erythropoietin modulation of podocalyxin within an erythroblast niche.
Preferential inhibition of malignant cell growth by CDDO in Waldenstrom macroglobulinemia.
Transgenic GATA1ie3.9int - DAPK2 mice exhibit low-grade anemia, deficient stress erythropoiesis, and compromised erythroblast survival.
Role of B-lymphocyte stimulator (BLyS) in Waldenstrom's macroglobulinemia.
Core epo receptor signaling circuits in adult bone marrow-derived primary pro-erythroblasts.
Death associated protein kinase 2 (DAPK2): A novel Epo-modulated apoptotic regulator of late erythropoiesis.
Kit PY567-directed signals are important for efficient erythroid progenitor cell proliferation and survival, and are attenuated by Kit PY569.
Lyn kinase supports primary erythroid progenitor cell development.
Assisting mechanisms during PY-null Epo receptor allele dependent steady-state erythropoiesis.
Stress erythropoiesis is not efficiently supported by a minimal Epo receptor phosphotyrosine-null allele.
DYRK3 activation mechanisms, PKA/CREB engagement and modulation of progenitor cell survival.
Dynamics of pro-erythroblasts growth and differentiation revealed through gene profiling.
Roles for Epo receptor Y343 (and Stat5) in Kit synergy.
Purification of developmentally staged erythroid progenitor cells in numbers sufficient for gene profiling of CFUe development.
SCF/Epo synergy in primary CFUe is mediated efficiently by Epo receptor phosphotyrosine-independent mechanisms.
An optimized primary cell system for investigators of regulated erythropoiesis: Developmentally synchronized splenic erythroid progenitor cells from thiamphenicol-treated transgenic mice.
Erythroid-restricted expression and repressive role for mDYRK3 dual-specificity kinase in CFUe development.
Critical, concentrations of FOG are required for alpha IIb gene activation via both GATA-1-dependent, and independent mechanisms.
SCF synergizes with Epo via Epo receptor (p)y-dependent and -independent routes, selectively enhances Epo/Jak2/STAT5-dependent bclx & bcl2 gene transcription, and is the primary activator of Erks.
Regulation of GATA-1 gene expression: Roles for FOG, GATA-1, EPO, and novel activating and repressing cis-domains.
Subtraction cloning and initial characterization of novel EPO-response genes.
Co-expression of GATA-1 and the Epo receptor in myeloid FDCW2 cells prolongs the cell cycle at G(1), attenuates proliferation and activates endogenous erythroid gene expression.
Pim1 inhibits cell death: Induction of Pim1 and Pim2 transcription via a minimal Epo receptor form and modulation of apoptosis upon the deregulated expression of Pim1.
Epo-induced hemoglobinization of SKT6 cells is blocked by a dominant-negative form of STAT5.
EPO signaling via minimal mitogenic receptor forms, and via STAT factors in differentiating erythroid SKT6-40 cells.
ROLES FOR JAK2 KINASE IN EPO-INDUCED MITOGENESIS, INHIBITED APOPTOSIS, AND ERYTHROID-DIFFERENTIATION
ASSOCIATION OF P85/P13-K WITH THE EPO RECEPTOR WITHIN THE EXTENDED BOX-2 DOMAIN, AND POSSIBLE ROLES FOR JAK-2 IN P13-K ACTIVATION
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