Positions

Research Areas research areas

Overview

  • We are interested in understanding how experiences shape and refine the brain across the lifespan. To do this, we combine a variety of systems and molecular neuroscience techniques to first try to establish how the brain supports cognitive flexibility, our ability to switch between goals and strategies, as well as how these processes come online and are maintained. Next, we ask how experiences such as exercise or drug use alter the parts of the brain that support cognitive flexibility. Ultimately, our goal is to understand how and whether these experience can be utilized to stave off age-related declines in cognitive ability and brain health.

    The Brain & Experience Lab is always interested in recruiting graduate students and post-docs interested in these types of questions. If that's you, please reach out!
  • Selected Publications

    Academic Article

    Year Title
    2024 Distinct Action Signals by Subregions in the Nucleus Accumbens during STOP-Change Performance.The Journal of Neuroscience.  44:e0020242024. 2024
    2024 Psilocybin decreases neural responsiveness and increases functional connectivity while preserving pure-tone frequency selectivity in mouse auditory cortex.Journal of Neurophysiology.  132:45-53. 2024
    2024 Optogenetic Inhibition of the Orbitofrontal Cortex Disrupts Inhibitory Control during Stop-Change Performance in Male Rats.eNeuro.  11:ENEURO.0015-ENEU24.2024. 2024
    2023 Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus–Prelimbic CircuitsBiological Psychiatry Global Open Science.  3:725-733. 2023
    2023 Pillar[6]MaxQ: A potent supramolecular host for in vivo sequestration of methamphetamine and fentanylChem.  9:881-900. 2023
    2022 Medial prefrontal cortex lesions disrupt prepotent action selection signals in dorsomedial striatumCurrent Biology.  32:3276-3287.e3. 2022
    2022 Anthracene‐Walled Acyclic CB[n] Receptors: in vitro and in vivo Binding Properties toward Drugs of AbuseChemMedChem: chemistry enabling drug discovery.  17. 2022
    2021 In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor.Chemistry: A European Journal.  27:17476-17486. 2021
    2021 Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula.The Journal of Neuroscience.  41:4667-4677. 2021
    2021 Reactive and Proactive Adaptation of Cognitive and Motor Neural Signals during Performance of a Stop-Change Task.Brain Sciences.  11:617. 2021
    2021 Prediction errors and valence: From single units to multidimensional encoding in the amygdala.Behavioural Brain Research.  404:113176. 2021
    2021 The ever-changing OFC landscape: What neural signals in OFC can tell us about inhibitory control.Behavioral Neuroscience.  135:129-137. 2021
    2021 In Vitro and In Vivo Sequestration of Phencyclidine by Me4 Cucurbit[8]uril*.Chemistry: A European Journal.  27:3098-3105. 2021
    2020 Neural Signals in Red Nucleus during Reactive and Proactive Adjustments in Behavior.The Journal of Neuroscience.  40:4715-4726. 2020
    2020 Anterior cingulate cortex is necessary for adaptation of action plansProceedings of the National Academy of Sciences of USA.  117:6196-6204. 2020
    2019 A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task.eLife.  8:e46323. 2019
    2019 Single Neurons in Anterior Cingulate Cortex Signal the Need to Change Action During Performance of a Stop-change Task that Induces Response CompetitionCerebral Cortex.  29:1020-1031. 2019
    2018 The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in rats.Learning and Memory.  25:461-473. 2018
    2018 Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100β.PLoS One.  13:e0195726. 2018
    2018 Firing of Putative Dopamine Neurons in Ventral Tegmental Area Is Modulated by Probability of Success during Performance of a Stop-Change Task.eNeuro.  5:ENEURO.0007-ENEU18.2018. 2018
    2016 Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism.eNeuro.  3:ENEURO.0196-ENEU16.2016. 2016
    2015 Physical exercise enhances cognitive flexibility as well as astrocytic and synaptic markers in the medial prefrontal cortex.PLoS One.  10:e0124859. 2015

    Article

    Year Title
    2024 Psilocybin biphasically modulates cortical and behavioral activity in mice 2024
    2019 Enduring consequences of perinatal fentanyl exposure in mice 2019

    Book

    Year Title
    2021 What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology 2021

    Teaching Activities

  • Neurobiology Laboratory I Taught course 2024
  • Neurobiology Laboratory I Taught course 2024
  • Neuroscience and Behavior I Taught course 2024
  • Education And Training

  • Ph.D. Psychology and Neuroscience, Princeton University
  • Full Name

  • Adam Brockett