Positions

Overview

  • General area of Interest and/or Specialty:

    Neurobiology of pain and anxiety, voltage-gated calcium channels, human genetics, comparative transcriptomics, neuropharmacology.
    Description of Current Research:

    Pain and anxiety are two highly prevalent neurological conditions in humans. Unfortunately, the currently available pharmacological treatments for these conditions have many undesirable side effects. The scarcity of specific treatments with a more favorable side effect profile drives my motivation to investigate the molecular mechanisms underlying pain and anxiety. In particular, I focus on the role of neuronal voltage-gated calcium channels and endocannabinoids in specific cell populations of the pain pathway and in brain areas implicated in anxiety-like behavior. Voltage-gated calcium channels are key players in the modulation of neuronal circuits associated with pain and anxiety. In addition, endocannabinoids are internal signaling molecules that relieve pain and anxiety, partially by inhibiting voltage-gated calcium channels. My goal is to understand the coupling of endocannabinoids to voltage-gated calcium channels in cell-specific neuronal populations during situations that induce anxiety or chronic pain. To achieve this goal, I use modern electrophysiological techniques coupled to optogenetics, unique genetic models, and behavior. In the long term, I am interested in finding new cell-specific targets to mitigate anxiety-like behavior and pain. To do this, I will compare whole-cell transcriptome across specific neuronal subpopulations that are highly linked to anxiety and pain. As part of extensive collaborations with human geneticists, I also study mutations in voltage-gated calcium channels that are linked to neurological disorders, including myoclonus dystonia and schizophrenia.

    If you are interested in doing exciting research in an environment that values diversity and the provision of high-quality mentorship, please contact me.
  • Publications

    Academic Article

    Year Title
    2019 Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.Molecular Brain.  12:81. 2019
    2019 Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.FEBS Open Bio.  9:1603-1616. 2019
    2019 Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International Journal of Molecular Sciences.  20:3537-3537. 2019
    2019 Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders 2019
    2017 Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway.Cell Calcium.  66:1-9. 2017
    2017 Manuscript Title: Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV 2.2 mRNA Exon Composition and CaV 2.2 Current SizeeNeuro.  4:ENEURO.0332-16.2017. 2017
    2016 A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity.Scientific Reports.  6:34233. 2016
    2015 Calcium channel CaVα1 splice isoforms-Tissue specificity and drug actionCurrent Molecular Pharmacology.  8:22-31. 2015
    2014 CACNA1B mutation is linked to unique myoclonus-dystonia syndromeHuman Molecular Genetics.  24:987-993. 2014
    2013 Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences.Biochimica et Biophysica Acta - General Subjects.  1828:1522-1529. 2013
    2013 Regulation of high‐voltage‐activated Ca2+ channel function, trafficking, and membrane stability by auxiliary subunitsWiley Interdisciplinary Reviews: Membrane Transport and Signaling.  2:207-220. 2013
    2013 Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel Ca v 2.2 pre-mRNAMolecular Pain.  9:67. 2013
    2012 Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms.Journal of Neuroscience.  32:10365-10369. 2012
    2012 Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit.Cell Calcium.  51:22-30. 2012
    2010 Opioid inhibition of N-type Ca 2+ channels and spinal analgesia couple to alternative splicingNature Neuroscience.  13:1249. 2010
    2009 The alpha(2)delta subunit augments functional expression and modifies the pharmacology of Ca(V)1.3 L-type channels.Cell Calcium.  46:282-292. 2009
    2009 Involvement of R‐type Ca2+ channels in neurotransmitter release from spinal dorsolateral funiculus terminals synapsing motoneuronsJournal of Comparative Neurology.  513:188-196. 2009
    2008 Histamine‐induced Ca2+ entry in human astrocytoma U373 MG cells: Evidence for involvement of store‐operated channelsJournal of Neuroscience Research.  86:3456-3468. 2008
    2007 Inhibition of recombinant N-type Ca(V) channels by the gamma 2 subunit involves unfolded protein response (UPR)-dependent and UPR-independent mechanisms.Journal of Neuroscience.  27:3317-3327. 2007
    2007 Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cellsFEBS Letters.  581:4430-4438. 2007
    2007 Proteolytic cleavage of the voltage‐gated Ca2+ channel α2δ subunit: structural and functional featuresEuropean Journal of Neuroscience.  25:1705-1710. 2007
    2006 Transforming growth factor‐β1 and bone morphogenetic protein‐2 downregulate CaV3. 1 channel expression in mouse C2C12 myoblastsJournal of Cellular Physiology.  209:448-456. 2006
    2004 Glycosylation of asparagines 136 and 184 is necessary for the α2δ subunit‐mediated regulation of voltage‐gated Ca2+ channelsFEBS Letters.  576:21-26. 2004
    Developmental and cell-specific expression of Cacna1d splice variants

    Teaching Activities

  • Honors Senior Thesis Taught course 2019
  • Investigations Biomedical Sci Taught course 2019
  • Neurobiology Laboratory I Taught course 2019
  • Neurobiology Laboratory I Taught course 2019
  • Neurobiology Laboratory I Taught course 2019
  • Neurobiology Laboratory I Taught course 2019
  • Neuroscience and Behavior I Taught course 2019
  • Neurbiology Taught course 2019
  • Senior Honors Thesis Taught course 2019
  • Special Investigations Taught course 2019
  • Neurobiology Laboratory I Taught course 2018
  • Neurobiology Laboratory I Taught course 2018
  • Neurobiology Laboratory I Taught course 2018
  • Neuroscience and Behavior I Taught course 2018
  • Neurbiology Taught course 2018
  • Adv Rsrch Exp/Biology Sciences Taught course 2017
  • Neurobiology Laboratory I Taught course 2017
  • Neurobiology Laboratory I Taught course 2017
  • Neurobiology Laboratory I Taught course 2017
  • Neuroscience and Behavior I Taught course 2017
  • Special Investigations Taught course 2017
  • Honors Senior Thesis Taught course 2017
  • Neurbiology Taught course 2017
  • Rsrch Exp/Biological Sciences Taught course 2017
  • Doctoral Research Taught course 2016
  • Honors Senior Thesis Taught course 2016
  • Neurobiology Laboratory I Taught course 2016
  • Neuroscience and Behavior I Taught course 2016
  • Neurobiology and Behavior Taught course 2016
  • Rsrch Exp/Biological Sciences Taught course 2016
  • Full Name

  • Arturo Andrade
  • Mailing Address

  • University of New Hampshire

    Biological Sciences

    46 College Road

    Durham, NH  03824

    United States